ArticleGenes and immunity2003
Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair.
Article in Genes and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 147 citations in OpenAlex.
- Molecular profiling of rheumatoid arthritis patients reveals an association between innate and adaptive cell populations and response to anti-tumor necrosis factor.Arthritis research & therapy · 2019Trial
- Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics.Arthritis research & therapy · 2014Trial
- Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients.Arthritis research & therapy · 2006Trial
- When inflammation is not the driver: Pauci-immune synovitis and the stromal basis of refractory arthritis.EULAR rheumatology open · 2026Review
- Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis.International journal of molecular sciences · 2025Review
- The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis.Nature communications · 2023Article
- Sequencing technology as a major impetus in the advancement of studies into rheumatism: A bibliometric study.Frontiers in immunology · 2023Article
- RNA Editing-Associated Post-Transcriptional Gene Regulation in Rheumatoid Arthritis.Bioinformatics and biology insights · 2022Article
- Understanding of sarcopenia: from definition to therapeutic strategies.Archives of pharmacal research · 2021Review
- Multiomics and Machine Learning Accurately Predict Clinical Response to Adalimumab and Etanercept Therapy in Patients With Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- Synovial tissue transcriptomes of long-standing rheumatoid arthritis are dominated by activated macrophages that reflect microbial stimulation.Scientific reports · 2020Article
- New Developments in Transcriptomic Analysis of Synovial Tissue.Frontiers in medicine · 2020Review
- Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Clinical Applications of Synovial Biopsy.Frontiers in medicine · 2019Review
- A Combined Transcriptomic and Genomic Analysis Identifies a Gene Signature Associated With the Response to Anti-TNF Therapy in Rheumatoid Arthritis.Frontiers in immunology · 2019Article
- CTHRC1: A New Candidate Biomarker for Improved Rheumatoid Arthritis Diagnosis.Frontiers in immunology · 2019Article
- Synovial Tissue Heterogeneity in Rheumatoid Arthritis and Changes With Biologic and Targeted Synthetic Therapies to Inform Stratified Therapy.Frontiers in medicine · 2019Review
- Moving towards a molecular taxonomy of autoimmune rheumatic diseases.Nature reviews. Rheumatology · 2018Review
- Rheumatoid Arthritis and miRNAs: A Critical Review through a Functional View.Journal of immunology research · 2018Review
- Is there a role of synovial biopsy in drug development?BMC musculoskeletal disorders · 2016Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is a heterogeneous disease. We used cDNA microarray technology to subclassify RA patients and disclose disease pathways in rheumatoid synovium. Hierarchical clustering of gene expression data identified two main groups of tissues (RA-I and RA-II). A total of 121 genes were significantly higher expressed in the RA-I tissues, whereas 39 genes were overexpressed in the RA-II tissues. Among the 121 genes overexpressed in RA-I tissues, a relative majority of nine genes are located on chromosome 6p21.3. An interpretation of biological processes that take place revealed that the gene expression profile in RA-I tissues is indicative for an adaptive immune response. The RA-II group showed expression of genes suggestive for fibroblast dedifferentiation. Within the RA-I group, two subgroups could be distinguished; the RA-Ia group showed predominantly immune-related gene activity, while the RA-Ib group showed an additional higher activity of genes indicative for the classical pathway of complement activation. All tissues except the RA-Ia subgroup showed elevated expression of genes involved in tissue remodeling. These results confirm the heterogeneous nature of RA and suggest the existence of distinct pathogenic mechanisms that contribute to RA. The differences in expression profiles provide opportunities to stratify patients based on molecular criteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.