ArticleProceedings of the National Academy of Sciences of the United States of America2003
Selective heteromeric assembly of cyclic nucleotide-gated channels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Systematic functional evaluation of CNGA1 missense variants associated with retinitis pigmentosa.Molecular medicine (Cambridge, Mass.) · 2026Article
- Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels.Channels (Austin, Tex.) · 2023Review
- Article
- Linking ploidy level with salinity tolerance: NADPH-dependent 'ROS-Ca2+ hub' in the spotlight.Journal of experimental botany · 2019Article
- Calmodulin confers calcium sensitivity to the stability of the distal intracellular assembly domain of Kv7.2 channels.Scientific reports · 2017Article
- Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans.Scientific reports · 2017Article
- Article
- CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactions.American journal of physiology. Cell physiology · 2013Article
- Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides.The Journal of general physiology · 2013Article
- Defective trafficking of cone photoreceptor CNG channels induces the unfolded protein response and ER-stress-associated cell death.The Biochemical journal · 2012Article
- Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14.Protein & cell · 2011Article
- Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels.Nature communications · 2011Article
- Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel.EMBO reports · 2010Article
- Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels.Circulation research · 2010Article
- Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro.Journal of virology · 2009Article
- Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil.Journal of molecular biology · 2008Article
- Signaling pathways that regulate the enhanced disease resistance of Arabidopsis "defense, no death" mutants.Molecular plant-microbe interactions : MPMI · 2008Article
- Function and dysfunction of CNG channels: insights from channelopathies and mouse models.Molecular neurobiology · 2007Review
- Article
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Authors and funding
3 authors.
Funding
Abstract
Many ion channels in vivo are heteromeric complexes with well defined subunit compositions. For some channels, domains have been identified that determine whether two or more subunit species are compatible in forming a complex. Nonetheless, an unsolved fundamental question is how the native composition of an ion channel is selected during assembly over functional alternatives, such as heteromeric complexes favored over homomers. Cyclic nucleotide-gated channels are tetramers and, in their native forms, are composed of A and B subunits. Although most A subunits can form functional homomeric channels when expressed alone, A/B heteromeric channels are selectively formed in the presence of a B subunit. Here, we show that this selective assembly of heteromeric channels requires a trimer-forming C-terminal leucine zipper (CLZ) domain recently identified in the distal C terminus of A, but not B, subunits. Thus, a CLZ-defective A subunit no longer forms predominantly A/B heteromeric channels with the B subunit. A mechanism for this specificity involving the trimerization of the CLZ domain is proposed.
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