ArticleJournal of bacteriology2003
Essentiality of clpX, but not clpP, clpL, clpC, or clpE, in Streptococcus pneumoniae R6.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Identification of intracellular target of antimicrobial peptide EWAMP-R in bacteria.Communications biology · 2026Article
- A toxin/antitoxin system targeting the replication sliding-clamp induces competence in Streptococcus pneumoniae.PLoS genetics · 2025Article
- Genome-wide identification of essential genes in the invasive Streptococcus anginosus strain.Scientific reports · 2025Article
- Genetic determinants of silver nanoparticle resistance and the impact of gamma irradiation on nanoparticle stability.BMC microbiology · 2025Article
- Biosynthesis of mitis group streptococcal glycolipids and their roles in physiology and antibiotic susceptibility.bioRxiv : the preprint server for biology · 2024Article
- Negative regulation of MurZ and MurA underlies the essentiality of GpsB- and StkP-mediated protein phosphorylation in Streptococcus pneumoniae D39.Molecular microbiology · 2023Article
- Genome-Wide Transposon Mutagenesis Screens Identify Group A Streptococcus Genes Affecting Susceptibility to β-Lactam Antibiotics.Journal of bacteriology · 2022Article
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae.PLoS pathogens · 2016Article
- The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host.Infection and immunity · 2016Article
- Effect of nonheme iron-containing ferritin Dpr in the stress response and virulence of pneumococci.Infection and immunity · 2014Article
- Natural genetic transformation generates a population of merodiploids in Streptococcus pneumoniae.PLoS genetics · 2013Article
- The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a.Journal of bacteriology · 2011Article
- Decrease in penicillin susceptibility due to heat shock protein ClpL in Streptococcus pneumoniae.Antimicrobial agents and chemotherapy · 2011Article
- Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans.Journal of bacteriology · 2010Article
- Virulence attenuation of Streptococcus pneumoniae clpP mutant by sensitivity to oxidative stress in macrophages via an NO-mediated pathway.Journal of microbiology (Seoul, Korea) · 2010Article
- Identification and characterization of noncoding small RNAs in Streptococcus pneumoniae serotype 2 strain D39.Journal of bacteriology · 2010Article
- spr1630 is responsible for the lethality of clpX mutations in Streptococcus pneumoniae.Journal of bacteriology · 2009Article
- Competence for genetic transformation in Streptococcus pneumoniae: termination of activity of the alternative sigma factor ComX is independent of proteolysis of ComX and ComW.Journal of bacteriology · 2009Article
- Role of Clp proteins in expression of virulence properties of Streptococcus mutans.Journal of bacteriology · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We show by using a regulated promoter that clpX of Streptococcus pneumoniae R6 is essential, whereas clpP, clpL, clpC, and clpE can be disrupted. The essentiality of clpX was initially missed because of duplication and rearrangement in the region of the chromosome containing clpX. Depletion of ClpX resulted in a rapid loss of viability without overt changes in cell morphology. Essentiality of clpX, but not clpP, has not been reported previously.
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