ArticleProceedings of the National Academy of Sciences of the United States of America2003
Moth chemosensory protein exhibits drastic conformational changes and cooperativity on ligand binding.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 155 citations in OpenAlex.
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- Coordinated sequestration and transcriptional regulation drive CSP2-mediated chlorpyrifos resistance in Nilaparvata lugens.Pest management science · 2026Article
- Functional Characterization of OasiCSP12: A Chemosensory Protein Regulating Olfaction and Phase Change inInsects · 2026Article
- Review
- Molecular Phylogeny of "Chemosensory Proteins" in Bacteria and Arthropods: CSP as an Extremely Ancient Gene.Journal of molecular evolution · 2026Article
- Chemosensory protein 3 is a brain host factor for the induction of enhanced-locomotory activity in the BmNPV-silkworm infection model.PLoS pathogens · 2025Article
- Review
- Expression Pattern and Ligand Binding Characteristics Analysis of Chemosensory Protein SnitCSP2 fromInsects · 2023Article
- An odorant binding protein is involved in counteracting detection-avoidance and Toll-pathway innate immunity.Journal of advanced research · 2023Article
- Odorant-binding Protein 10 From Bradysia odoriphaga (Diptera: Sciaridae) Binds Volatile Host Plant Compounds.Journal of insect science (Online) · 2023Article
- Role of Acrostyle Cuticular Proteins in the Retention of an Aphid Salivary Effector.International journal of molecular sciences · 2022Article
- Review
- Transcriptome analysis and molecular characterization of soluble chemical communication proteins in the parasitoid waspEcology and evolution · 2022Article
- Chemosensory protein 4 is required forFrontiers in physiology · 2022Article
- Heavy Atom Detergent/Lipid Combined X-ray Crystallography for Elucidating the Structure-Function Relationships of Membrane Proteins.Membranes · 2021Review
- The Crystal Structure of theInsects · 2021Article
- A new non-classical fold of varroa odorant-binding proteins reveals a wide open internal cavity.Scientific reports · 2021Article
- Isolation, Identification, and Bioinformatic Analysis of Antibacterial Proteins and Peptides from Immunized Hemolymph of Red Palm WeevilBiomolecules · 2021Article
- Comparison and Functional Analysis of Chemosensory Protein Genes FromFrontiers in physiology · 2021Article
- Molecular Modeling of Chemosensory Protein 3 fromInternational journal of molecular sciences · 2020Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemosensory proteins (CSPs) have been proposed to transport hydrophobic chemicals from air to olfactory or taste receptors. They have been isolated from several sensory organs of a wide range of insect species. The x-ray structure of CSPMbraA6, a 112-aa antennal protein from the moth Mamestra brassicae (Mbra), was shown to exhibit a novel type of alpha-helical fold. We have performed a structural and binding study of CSPMbraA6 to get some insights into its possible molecular function. Tryptophan fluorescence quenching demonstrates the ability of CSPMbraA6 to bind several types of semio-chemicals or surrogate ligands with microM K(d). Its crystal structure in complex with one of these compounds, 12-bromo-dodecanol, reveals extensive conformational changes on binding, resulting in the formation of a large cavity filled by three ligand molecules. Furthermore, binding cooperativity was demonstrated for some ligands, suggesting a stepwise binding. The peculiar rearrangement of CSPMbraA6 conformation and the cooperativity phenomenon might trigger the recognition of chemicals by receptors and induce subsequent signal transduction.
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