ArticleMolecular and cellular biology2003
Replication proteins influence the maintenance of telomere length and telomerase protein stability.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Investigating RFC1 expansions in sporadic amyotrophic lateral sclerosis.Journal of the neurological sciences · 2021Article
- Ssu72 phosphatase is a conserved telomere replication terminator.The EMBO journal · 2019Article
- Regulating telomere length from the inside out: the replication fork model.Genes & development · 2016Article
- DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing.Molecular cancer research : MCR · 2015Article
- Role of swi7H4 mutant allele of DNA polymerase α in the DNA damage checkpoint response.PloS one · 2015Article
- SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.PLoS genetics · 2013Article
- Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe.Genetics · 2012Article
- Mapping the FEN1 interaction domain with hTERT.Biochemical and biophysical research communications · 2011Article
- Replication-compromised cells require the mitotic checkpoint to prevent tetraploidization.Chromosoma · 2011Article
- Telomere replication: poised but puzzling.Journal of cellular and molecular medicine · 2011Review
- Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus.The Journal of biological chemistry · 2009Article
- Protection and replication of telomeres in fission yeast.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2009Review
- Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.The EMBO journal · 2009Article
- Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance.The Journal of biological chemistry · 2009Article
- Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination.Genetics · 2007Article
- Role of SUMO in the dynamics of telomere maintenance in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha.Molecular and cellular biology · 2005Article
- Limited TTP supply affects telomere length regulation in a telomerase-independent fashion.Nucleic acids research · 2005Article
- A coordinated temporal interplay of nucleosome reorganization factor, sister chromatin cohesion factor, and DNA polymerase alpha facilitates DNA replication.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effects of fission yeast replication genes on telomere length maintenance and identified 20 mutant alleles that confer lengthening or shortening of telomeres. The telomere elongation was telomerase dependent in the replication mutants analyzed. Furthermore, the telomerase catalytic subunit, Trt1, and the principal initiation and lagging-strand synthesis DNA polymerase, Polalpha, were reciprocally coimmunoprecipitated, indicating these proteins physically coexist as a complex in vivo. In a polalpha mutant that exhibited abnormal telomere lengthening and slightly reduced telomere position effect, the cellular level of the Trt1 protein was significantly lower and the coimmunoprecipitation of Trt1 and Polalpha was severely compromised compared to those in the wild-type polalpha cells. Interestingly, ectopic expression of wild-type polalpha in this polalpha mutant restored the cellular Trt1 protein to the wild-type level and shortened the telomeres to near-wild-type length. These results suggest that there is a close physical relationship between the replication and telomerase complexes. Thus, mutation of a component of the replication complex can affect the telomeric complex in maintaining both telomere length equilibrium and telomerase protein stability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.