ArticleBMC microbiology2003
Staphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblasts.
Article in BMC microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 84 citations in OpenAlex.
- Osteomyelitis.Nature reviews. Disease primers · 2026Review
- HIF-1α at the intersection of hypoxia, ferroptosis-associated stress, and cell death crosstalk in osteomyelitis.Frontiers in cell and developmental biology · 2026Review
- Article
- Review
- The influence of marine fungal meroterpenoid meroantarctine A toward HaCaT keratinocytes infected with Staphylococcus aureus.The Journal of antibiotics · 2024Article
- Advanced Antimicrobial and Anti-Infective Strategies to Manage Peri-Implant Infection: A Narrative Review.Dentistry journal · 2024Review
- Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies.Biomaterials research · 2022Review
- Osteomyelitis, Oxidative Stress and Related Biomarkers.Antioxidants (Basel, Switzerland) · 2022Review
- Rifampicin restores extracellular organic matrix formation and mineralization of osteoblasts after intracellularBone & joint research · 2022Article
- Current opinions on the mechanism, classification, imaging diagnosis and treatment of post-traumatic osteomyelitis.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2021Review
- 3D Cocultures of Osteoblasts andPathogens (Basel, Switzerland) · 2021Article
- The Crossroads between Infection and Bone Loss.Microorganisms · 2020Review
- Localized mandibular infection affects remote in vivo bioreactor bone generation.Biomaterials · 2020Article
- Review
- Selective Host Cell Death byFrontiers in immunology · 2020Review
- The Process of Osteoblastic Infection byInternational journal of medical sciences · 2020Review
- Impact of Bacterial Infections on Osteogenesis: Evidence From In Vivo Studies.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Review
- Implant infections: adhesion, biofilm formation and immune evasion.Nature reviews. Microbiology · 2018Review
- Pathogenic Mechanisms and Host Interactions inFrontiers in microbiology · 2017Review
- Distinct roles of TNF-related apoptosis-inducing ligand (TRAIL) in viral and bacterial infections: from pathogenesis to pathogen clearance.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundStaphylococcus aureus infection of normal osteoblasts induces expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
resultsNormal osteoblasts were incubated in the presence of purified bacterial products over a range of concentrations. Results demonstrate that purified surface structures and a selected superantigen present in the extracellular environment are not capable of inducing TRAIL expression by osteoblasts. Osteoblasts were co-cultured with S. aureus at various multiplicities of infection utilizing cell culture chamber inserts. Results of those experiments suggest that direct contact between bacteria and osteoblasts is necessary for optimal TRAIL induction. Finally, S. aureus infection of osteoblasts in the presence of anti-TRAIL antibody demonstrates that TRAIL mediates caspase-8 activation and apoptosis of infected cells.
conclusionsCollectively, these findings suggest a mechanism whereby S. aureus mediates bone destruction via induction of osteoblast apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.