ArticleCurrent genetics2003
Genetic background affects relative nonsense mRNA accumulation in wild-type and upf mutant yeast strains.
Article in Current genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Global effect of copper excess and deficiency in Saccharomyces cerevisiae proficient or deficient in nonsense-mediated mRNA decay.Genomics · 2025Article
- Nonsense-mediated mRNA decay of metal-binding activator MAC1 is dependent on copper levels and 3'-UTR length in Saccharomyces cerevisiae.Current genetics · 2024Article
- Variation of the response to metal ions and nonsense-mediated mRNA decay across different Saccharomyces cerevisiae genetic backgrounds.Yeast (Chichester, England) · 2021Article
- How to get away with nonsense: Mechanisms and consequences of escape from nonsense-mediated RNA decay.Wiley interdisciplinary reviews. RNA · 2020Review
- Nonsense-mediated mRNA decay of the ferric and cupric reductase mRNAs FRE1 and FRE2 in Saccharomyces cerevisiae.FEBS letters · 2019Article
- The nonsense-mediated mRNA decay (NMD) pathway differentially regulates COX17, COX19 and COX23 mRNAs.Current genetics · 2019Article
- Measurement of mRNA decay rates in Saccharomyces cerevisiae using rpb1-1 strains.Journal of visualized experiments : JoVE · 2014Article
- The expression of PHO92 is regulated by Gcr1, and Pho92 is involved in glucose metabolism in Saccharomyces cerevisiae.Current genetics · 2014Article
- Immunity of the Saccharomyces cerevisiae SSY5 mRNA to nonsense-mediated mRNA decay.Frontiers in molecular biosciences · 2014Article
- When a ribosome encounters a premature termination codon.BMB reports · 2013Review
- Multiple transcripts from a 3'-UTR reporter vary in sensitivity to nonsense-mediated mRNA decay in Saccharomyces cerevisiae.PloS one · 2013Article
- Copper tolerance of Saccharomyces cerevisiae nonsense-mediated mRNA decay mutants.Current genetics · 2011Article
- Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.BMC molecular biology · 2011Article
- Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeast.Nucleic acids research · 2010Article
- The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors.Nucleic acids research · 2010Article
- Global analysis of alternative splicing uncovers developmental regulation of nonsense-mediated decay in C. elegans.RNA (New York, N.Y.) · 2009Article
- Long 3'-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae.Nucleic acids research · 2009Article
- The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway.Nucleic acids research · 2007Article
- A subset of Mer1p-dependent introns requires Bud13p for splicing activation and nuclear retention.RNA (New York, N.Y.) · 2006Article
- Ebs1p, a negative regulator of gene expression controlled by the Upf proteins in the yeast Saccharomyces cerevisiae.Eukaryotic cell · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Saccharomyces cerevisiae nonsense-mediated mRNA decay (NMD) pathway targets mRNAs with premature stop codons and some wild-type mRNAs for accelerated decay. Upf1p, Upf2p and Upf3p are required for NMD. NMD-targeted mRNAs are degraded rapidly in wild-type cells and stabilized in upf1, upf2 or upf3 mutants. We report here that the relative CYH2 pre-mRNA/mRNA accumulation is enhanced in cells derived from a W303 background, compared with a variety of commonly used strains. The enhanced CYH2 pre-mRNA accumulation phenotype results from a larger difference in mRNA half-lives in the W303 strains than two previously used strains. This phenotype can be selected in crosses and is also seen in upf2 and upf3 mutants. These results suggest there are genes that influence the efficiency of NMD and that yeast strains derived from the W303 background may be useful for measurement of abundance and half-lives of low abundance, short-lived NMD substrates.
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