ArticleThe Journal of cell biology2003
Speract induces calcium oscillations in the sperm tail.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 100 citations in OpenAlex.
- Decoding the Bell-Shaped Calcium Spikes in Phosphorylation Cycles of Flagella.International journal of molecular sciences · 2022Article
- PMCA4 gene expression is regulated by the androgen receptor in the mouse testis during spermatogenesis.Molecular medicine reports · 2021Article
- Article
- Modular analysis of the control of flagellar Ca2+-spike trains produced by CatSper and CaV channels in sea urchin sperm.PLoS computational biology · 2020Article
- A coordinated sequence of distinct flagellar waveforms enables a sharp flagellar turn mediated by squid sperm pH-taxis.Scientific reports · 2017Article
- Network model predicts that CatSper is the main CaScientific reports · 2017Article
- Article
- Soluble adenylyl cyclase of sea urchin spermatozoa.Biochimica et biophysica acta · 2014Review
- Zn(2+) induces hyperpolarization by activation of a K(+) channel and increases intracellular Ca(2+) and pH in sea urchin spermatozoa.Developmental biology · 2014Review
- Intracellular pH in sperm physiology.Biochemical and biophysical research communications · 2014Review
- Sperm guidance to the egg finds calcium at the helm.Protoplasma · 2014Review
- T-type Ca2+ channels in spermatogenic cells and sperm.Pflugers Archiv : European journal of physiology · 2014Review
- Article
- Calaxin drives sperm chemotaxis by Ca²⁺-mediated direct modulation of a dynein motor.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility.Journal of cellular physiology · 2012Article
- What is the core oscillator in the speract-activated pathway of the Strongylocentrotus purpuratus sperm flagellum?Biophysical journal · 2012Article
- The rate of change in Ca(2+) concentration controls sperm chemotaxis.The Journal of cell biology · 2012Article
- Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility.Molecular reproduction and development · 2012Review
- Strategies for locating the female gamete: the importance of measuring sperm trajectories in three spatial dimensions.Molecular human reproduction · 2011Review
- Discrete dynamics model for the speract-activated Ca2+ signaling network relevant to sperm motility.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sea urchin sperm motility is modulated by sperm-activating peptides. One such peptide, speract, induces changes in intracellular free calcium concentration ([Ca2+]i). High resolution imaging of single sperm reveals that speract-induced changes in [Ca2+]i have a complex spatiotemporal structure. [Ca2+]i increases arise in the tail as periodic oscillations; [Ca2+]i increases in the sperm head lag those in the tail and appear to result from the summation of the tail signal transduction events. The period depends on speract concentration. Infrequent spontaneous [Ca2+]i transients were also seen in the tail of unstimulated sperm, again with the head lagging the tail. Speract-induced fluctuations were sensitive to membrane potential and calcium channel blockers, and were potentiated by niflumic acid, an anion channel blocker. 3-isobutyl-1-methylxanthine, which potentiates the cGMP/cAMP-signaling pathways, abolished the [Ca2+]i fluctuations in the tail, leading to a very delayed and sustained [Ca2+]i increase in the head. These data point to a model in which a messenger generated periodically in the tail diffuses to the head. Sperm are highly polarized cells. Our results indicate that a clear understanding of the link between [Ca2+]i and sperm motility will only be gained by analysis of [Ca2+]i signals at the level of the single sperm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.