ReviewCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2003
Risks and benefits of hormone replacement therapy: the evidence speaks.
Review in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Saudi National Clinical Practice Guidelines for Management of Adult Systemic Lupus Erythematosus.Current rheumatology reviews · 2025Guideline
- Efficacy ofNutrients · 2024Trial
- Understanding breast cancer causes: insights from Jordanian women's awareness.Future science OA · 2026Article
- Observational
- Understanding Hypoactive Sexual Desire Disorder (HSDD) in Women: Etiology, Diagnosis, and Treatment.Cureus · 2023Review
- Modulation of vulvovaginal atrophy (VVA) by Gelam honey in bilateral oophorectomized rats.Frontiers in endocrinology · 2023Article
- Modulatory role of genistein on placenta and maternal bone minerals composition: further insight into its influence on pregnancy and foetal development.Biologia futura · 2020Article
- Royal Jelly-A Traditional and Natural Remedy for Postmenopausal Symptoms and Aging-Related Pathologies.Molecules (Basel, Switzerland) · 2020Review
- The Effect ofJournal of clinical medicine · 2020Article
- Estrogenic Effect of the Extract of QingYan Formula on Reproductive Tissues in Immature Mice.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Protective effect ofAnatomy & cell biology · 2017Article
- Article
- Short-time QiBaoMeiRan Formula Treatment Exerts Estrogenic Activities without Side Effects on Reproductive Tissues in Immature Mice.Scientific reports · 2015Article
- Treatment with qibaomeiran, a kidney-invigorating Chinese herbal formula, antagonizes estrogen decline in ovariectomized rats.Rejuvenation research · 2014Article
- [Frederick Banting and the opportunities for research for general practitioners].CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2011Article
- Frederick Banting and the opportunities of research by general practitioners.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2011Article
- Effect of hormone replacement therapy (HRT) on periodontal status of postmenopausal women.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Estrogen prevents sustained COLO-205 human colon cancer cell growth by inducing apoptosis, decreasing c-myb protein, and decreasing transcription of the anti-apoptotic protein bcl-2.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2010Article
- Long-term efficacy and safety of anastrozole for adjuvant treatment of early breast cancer in postmenopausal women.Therapeutics and clinical risk management · 2009Article
- Estrogenic activities of Fatty acids and a sterol isolated from royal jelly.Evidence-based complementary and alternative medicine : eCAM · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Until recently, observational studies suggested a decreased risk of cardiovascular disease, osteoporotic fractures, cognitive decline and colon cancer with the use of hormone replacement therapy (HRT). Recent randomized controlled trials have failed to show a protective effect of HRT in reducing the risk of coronary artery disease and instead have revealed an increased risk of heart disease, stroke, invasive breast cancer and venous thromboembolism, but a decreased risk of colorectal cancer and osteoporotic fractures. In this article we review the current evidence of the risks and benefits of HRT.
Indexed as
Identifiers
12695385PMC152685W2119183925What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.