ArticleGenome research2003
Predicting human minisatellite polymorphism.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- A family portrait of the genomic factors shaping tandem repeat mutagenesis.bioRxiv : the preprint server for biology · 2026Article
- Genome-wide characterization of human minisatellite VNTRs: population-specific alleles and gene expression differences.Nucleic acids research · 2021Article
- Length Polymorphism and Methylation Status of UPS29 Minisatellite of theInternational journal of molecular sciences · 2020Article
- Extreme enrichment of VNTR-associated polymorphicity in human subtelomeres: genes with most VNTRs are predominantly expressed in the brain.Translational psychiatry · 2020Article
- VNTRseek-a computational tool to detect tandem repeat variants in high-throughput sequencing data.Nucleic acids research · 2014Article
- A Whole Genome Screen for Minisatellite Stability Genes in Stationary-Phase Yeast Cells.G3 (Bethesda, Md.) · 2013Article
- Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity.PloS one · 2010Article
- Sexual selection does not influence minisatellite mutation rate.BMC evolutionary biology · 2009Article
- Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2008Review
- Article
- Multiple-locus variable-number tandem-repeat analysis as a tool for subtyping Listeria monocytogenes strains.Journal of clinical microbiology · 2008Article
- Sequence-based estimation of minisatellite and microsatellite repeat variability.Genome research · 2007Article
- TRDB--the Tandem Repeats Database.Nucleic acids research · 2007Article
- Tools for the identification of variable and potentially variable tandem repeats.BMC genomics · 2006Article
- Complex minisatellite rearrangements generated in the total or partial absence of Rad27/hFEN1 activity occur in a single generation and are Rad51 and Rad52 dependent.Molecular and cellular biology · 2006Article
- Evaluation and selection of tandem repeat loci for a Brucella MLVA typing assay.BMC microbiology · 2006Article
- Tandem repeat copy-number variation in protein-coding regions of human genes.Genome biology · 2005Article
- Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Tandem repeats analysis for the high resolution phylogenetic analysis of Yersinia pestis.BMC microbiology · 2004Article
- Identification of polymorphic tandem repeats by direct comparison of genome sequence from different bacterial strains: a web-based resource.BMC bioinformatics · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We seek to define sequence-based predictive criteria to identify polymorphic and hypermutable minisatellites in the human genome. Polymorphism of a representative pool of minisatellites, selected from human chromosomes 21 and 22, was experimentally measured by PCR typing in a population of unrelated individuals. Two predictive approaches were tested. One uses simple repeat characteristics (e.g., unit length, copy number, nucleotide bias) and a more complex measure, termed HistoryR, based on the presence of variant motifs in the tandem array. We find that HistoryR and percentage of GC are strongly correlated with polymorphism and, as predictive criteria, reduce by half the number of repeats to type while enriching the proportion with heterozygosity >/=0.5, from a background level of 43% to 59%. The second approach uses length differences between minisatellites in the two releases of the human genome sequence (from the public consortium and Celera). As a predictor, this similarly enriches the number of polymorphic minisatellites, but fails to identify an unexpectedly large number of these. Finally, typing of the highly polymorphic minisatellites in large families identified one new hypermutable minisatellite, located in a predicted coding sequence. This may represent the first coding human hypermutable minisatellite.
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