ArticleEnvironmental health : a global access science source2003
Decreased sex ratio following maternal exposure to polychlorinated biphenyls from contaminated Great Lakes sport-caught fish: a retrospective cohort study.
Article in Environmental health : a global access science source, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- A State of the Science Review of Human Health Effects of the Michigan Polybrominated Biphenyl Contamination after Five Decades.Environmental health perspectives · 2025Review
- Article
- Seasonal variation in air pollutant levels and its effects on the sex ratio at birth on Fukue island, Japan.BMC public health · 2023Article
- Effects of dioxins on animal spermatogenesis: A state-of-the-art review.Frontiers in reproductive health · 2022Review
- Maternal exposure to airborne polychlorinated biphenyls (PCBs) and risk of adverse birth outcomes.European journal of epidemiology · 2021Article
- Maternal and paternal serum concentrations of persistent organic pollutants and the secondary sex ratio: A population-based preconception cohort study.Environmental research · 2018Article
- Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury.International journal of circumpolar health · 2017Article
- In utero exposure to polychlorinated biphenyls is associated with decreased fecundability in daughters of Michigan female fisheaters: a cohort study.Environmental health : a global access science source · 2016Article
- Increasing sample size in prospective birth cohorts: back-extrapolating prenatal levels of persistent organic pollutants in newly enrolled children.Environmental science & technology · 2015Article
- Regional Variation in Human Exposure to Persistent Organic Pollutants in the United States, NHANES.Journal of environmental and public health · 2015Article
- Exposure to persistent organic pollutants and sperm sex chromosome ratio in men from the Faroe Islands.Environment international · 2014Article
- Girl or boy? Prenatal lead, cadmium and mercury exposure and the secondary sex ratio in the ALSPAC study.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Can environmental or occupational hazards alter the sex ratio at birth? A systematic review.Emerging health threats journal · 2011Article
- Maternal exposure to polychlorinated biphenyls and the secondary sex ratio: an occupational cohort study.Environmental health : a global access science source · 2011Article
- A cohort study of the association between secondary sex ratio and parental exposure to polybrominated biphenyl (PBB) and polychlorinated biphenyl (PCB).Environmental health : a global access science source · 2009Article
- Towards integration of environmental and health impact assessments for wild capture fishing and farmed fish with particular reference to public health and occupational health dimensions.International journal of environmental research and public health · 2008Review
- A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio.Environmental health : a global access science source · 2008Article
- Effects of perinatal polychlorinated biphenyls on adult female rat reproduction: development, reproductive physiology, and second generational effects.Biology of reproduction · 2008Article
- Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident.Environmental health perspectives · 2008Article
- Secondary sex ratio among women exposed to diethylstilbestrol in utero.Environmental health perspectives · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFish from the Great Lakes are contaminated with polychlorinated biphenyls, which have been found to have several adverse reproductive effects. Several environmental contaminants have been found to alter the sex ratio of offspring at birth, but the evidence of such an effect of polychlorinated biphenyls has been inconsistent.
methodsWe examined parental serum polychlorinated biphenyl concentration in relation to the sex ratio of 173 children of mothers and 208 children of fathers from the Great Lakes region of the United States between 1970 and 1995. We calculated odds ratios for a male child using logistic regression and generalized estimating equations with adjustment for the year of birth of the child, maternal and paternal age, the mother's parity at the child's birth, and whether the child had an older brother.
resultsThe adjusted odds ratio for having a male child among mothers in the highest quintile of serum polychlorinated biphenyl concentration was 0.18 (95% CI: 0.06-0.59) compared to mothers in the lowest quintile. Treating exposure as a continuous variable, the adjusted odds ratio for having a male child was 0.54 per unit increase in the natural log of maternal serum polychlorinated biphenyl concentration (95% CI: 0.33-0.89). There was little evidence of an association with paternal exposure. We found no association between either maternal or paternal serum dichlorodiphenyl-dichloroethene concentration and the sex ratio.
conclusionsThese findings suggest that maternal exposure to polychlorinated biphenyls may decrease the sex ratio of offspring. These data add to the growing body of evidence that exposure to particular chemicals can alter the sex ratio at birth.
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