Trial reportPsychopharmacology2003
Effects of sertraline on autonomic and cognitive functions in healthy volunteers.
Trial report in Psychopharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- The effects of selective serotonin reuptake inhibitors on memory functioning in older adults: A systematic literature review.Journal of psychopharmacology (Oxford, England) · 2022Pooled it
- The association between electrodermal activity (EDA), depression and suicidal behaviour: A systematic review and narrative synthesis.BMC psychiatry · 2018Pooled it
- Effect of paroxetine on physiological response to stress and smoking.Psychosomatic medicine · 2013Trial
- Acute treatment with the antidepressants bupropion and sertraline do not influence memory retrieval in man.European archives of psychiatry and clinical neuroscience · 2006Trial
- Effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression.Psychopharmacology · 2004Trial
- Event-Related Potential Markers of Suicidality in Adolescents.The international journal of neuropsychopharmacology · 2023Article
- Associations between psychotropic drugs and rsEEG connectivity and network characteristics: a cross-sectional study in hospital-admitted psychiatric patients.Frontiers in neuroscience · 2023Article
- Heart Rate Variability: A Measure of Cardiovascular Health and Possible Therapeutic Target in Dysautonomic Mental and Neurological Disorders.Applied psychophysiology and biofeedback · 2022Review
- The negative effects of social bond disruption are partially ameliorated by sertraline administration in prairie voles.Autonomic neuroscience : basic & clinical · 2019Article
- Evaluation of Heart Rate Variability in Drug Free Panic Disorder Patients.Noro psikiyatri arsivi · 2018Article
- How Anxious Do You Think I Am? Relationship Between State and Trait Anxiety in Children With and Without ASD During Social Tasks.Journal of autism and developmental disorders · 2017Article
- Serotonin and brain function: a tale of two receptors.Journal of psychopharmacology (Oxford, England) · 2017Review
- Altered Behavioral and Autonomic Pain Responses in Alzheimer's Disease Are Associated with Dysfunctional Affective, Self-Reflective and Salience Network Resting-State Connectivity.Frontiers in aging neuroscience · 2017Article
- Article
- Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions.International journal of geriatric psychiatry · 2016Article
- Treating Chronic Pain with SSRIs: What Do We Know?Pain research & management · 2016Review
- Cognitive functioning throughout the treatment history of clinical late-life depression.International journal of geriatric psychiatry · 2015Article
- Appetite loss and neurocognitive deficits in late-life depression.International journal of geriatric psychiatry · 2015Article
- Cortisol and α-Amylase Secretion Patterns between and within Depressed and Non-Depressed Individuals.PloS one · 2015Article
- Blunted autonomic reactivity to pharmacological panic challenge under long-term escitalopram treatment in healthy men.The international journal of neuropsychopharmacology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThough sertraline, a selective serotonin reuptake inhibitor (SSRI), causes autonomic and cognitive adverse events such as dry mouth and somnolence, there is a paucity of appropriately designed studies on the cognitive and autonomic effects of the drug in the literature.
objectiveTo compare the effects of sertraline on cognitive and autonomic functions with those of placebo in healthy humans.
methodA randomized, double blind, cross over study of 12 healthy male volunteers aged 24 (21- 32; median; range) years. Subjects orally received 50 mg sertraline and placebo once daily for periods of 14 days each with at least 14 days in between. Heart rate variability (HRV), skin conductance level (SCL) and skin conductance response (SCR) following sudden deep respiration were employed as parameters for autonomic function. Quantitative EEG (qEEG) and psychometric tests served as parameters for cognitive function. Measurements were performed repeatedly before the start of drug administration and on the last treatment day.
resultsSertraline caused a significant reduction of heart rate and SCL ( P<0.05), whereas HRV and SCR were not changed. Cognitive functions such as flicker fusion frequency, memory, choice reaction time and psychomotor performance were not influenced by sertraline but slow and fast beta power density in the qEEG was increased.
conclusionCognitive and psychomotor performance are not altered in healthy humans receiving multiple dosing with sertraline. The observed decreases in heart rate and SCL may be due to a sympatho-inhibitory effect of sertraline.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.