ReviewGene therapy2003
Gene therapy progress and prospects: gene therapy in organ transplantation.
Review in Gene therapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Review
- ESOT Roadmap for Advanced Therapy Medicinal Products in Transplantation: Navigating Regulatory Challenges to Enhance Access and Care.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin.Journal of biological engineering · 2017Review
- Investigating the effects of block versus statistical glycopolycations containing primary and tertiary amines for plasmid DNA delivery.Biomacromolecules · 2014Article
- The site of allergen expression in hematopoietic cells determines the degree and quality of tolerance induced through molecular chimerism.European journal of immunology · 2013Article
- Persistent molecular microchimerism induces long-term tolerance towards a clinically relevant respiratory allergen.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
- Antigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritis.Seminars in arthritis and rheumatism · 2008Review
- Inhibition of CD26 peptidase activity significantly improves engraftment of retrovirally transduced hematopoietic progenitors.Gene therapy · 2006Article
- Prevention of type 1 diabetes by gene therapy.The Journal of clinical investigation · 2004Article
- Influence of liver nonparenchymal cell infusion combined with cyclosporin A on rejection of rat small bowel transplantation.World journal of gastroenterology · 2003Article
- Gene therapy for gastric cancer: a review.World journal of gastroenterology · 2003Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
One major complication facing organ transplant recipients is the requirement for life-long systemic immunosuppression to prevent rejection, which is associated with an increased incidence of malignancy and susceptibility to opportunistic infections. Gene therapy has the potential to eliminate problems associated with immunosuppression by allowing the production of immunomodulatory proteins in the donor grafts resulting in local rather than systemic immunosuppression. Alternatively, gene therapy approaches could eliminate the requirement for general immunosuppression by allowing the induction of donor-specific tolerance. Gene therapy interventions may also be able to prevent graft damage owing to nonimmune-mediated graft loss or injury and prevent chronic rejection. This review will focus on recent progress in preventing transplant rejection by gene therapy.
Indexed as
Identifiers
12692588What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.