ArticleNature neuroscience2003
Addition of inhibition in the olivocerebellar system and the ontogeny of a motor memory.
Article in Nature neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed.
- A transient feature of the inferior olive supports the development of cerebellar internal models.bioRxiv : the preprint server for biology · 2025Article
- Early insights into eyeblink conditioning using optically pumped magnetometer-based MEG.Frontiers in human neuroscience · 2025Article
- Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmentally unique cerebellar processing prioritizes self-over other-generated movements.bioRxiv : the preprint server for biology · 2024Article
- Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus.Current biology : CB · 2021Article
- Quantitative but Not Qualitative Performance Changes in Predictive Motor Timing as a Result of Overtraining.Cerebellum (London, England) · 2020Article
- Cerebellar contribution to locomotor behavior: A neurodevelopmental perspective.Neurobiology of learning and memory · 2019Review
- Inactivation of the interpositus nucleus during unpaired extinction does not prevent extinction of conditioned eyeblink responses or conditioning-specific reflex modification.Behavioral neuroscience · 2019Article
- Delayed Complex Spike Response Evoked by Conditioned Stimulus Encodes Movement Onset Time and Is Determined by Intrinsic Inferior Olive Properties.Frontiers in systems neuroscience · 2019Article
- Article
- Inactivation of the interpositus nucleus blocks the acquisition of conditioned responses and timing changes in conditioning-specific reflex modification of the rabbit eyeblink response.Neurobiology of learning and memory · 2018Article
- Oscillations, Timing, Plasticity, and Learning in the Cerebellum.Cerebellum (London, England) · 2016Review
- Climbing fibers encode a temporal-difference prediction error during cerebellar learning in mice.Nature neuroscience · 2015Article
- Cerebellar learning mechanisms.Brain research · 2015Review
- Ontogeny of septohippocampal modulation of delay eyeblink conditioning.Developmental psychobiology · 2015Article
- Integration of Purkinje cell inhibition by cerebellar nucleo-olivary neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Extinction, reacquisition, and rapid forgetting of eyeblink conditioning in developing rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Coding of stimulus strength via analog calcium signals in Purkinje cell dendrites of awake mice.eLife · 2014Article
- Sensory system development influences the ontogeny of eyeblink conditioning.Developmental psychobiology · 2014Article
- Persistent activity in a cortical-to-subcortical circuit: bridging the temporal gap in trace eyelid conditioning.Journal of neurophysiology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The developmental emergence of learning has traditionally been attributed to the maturation of single brain regions necessary for learning in adults, rather than to the maturation of synaptic interactions within neural systems. Acquisition and retention of a simple form of motor learning, classical conditioning of the eyeblink reflex, depends on the cerebellum and interconnected brainstem structures, including the inferior olive. Here, we combined unit recordings from Purkinje cells in eye regions of the cerebellar cortex and quantitative electron microscopy of the inferior olive to show that the developmental emergence of eyeblink conditioning in rats is associated with the maturation of inhibitory feedback from the cerebellum to the inferior olive. The results are consistent with previous work in adult animals and indicate that the maturation of cerebellar inhibition within the inferior olive may be a critical factor for the formation and retention of learning-specific cerebellar plasticity and eyeblink conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.