Evidence map›Paper›PMID 12692211›Full record

ArticleJournal of virology2003

Analysis of 4.3 kilobases of divergent locus B of macaque retroperitoneal fibromatosis-associated herpesvirus reveals a close similarity in gene sequence and genome organization to Kaposi's sarcoma-associated herpesvirus.

Timothy M Rose, Jonathan T Ryan, Emily R Schultz, Brian W Raden, Che-Chung Tsai

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Timothy M RoseDepartment of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA. trose@u.washington.edu
Jonathan T Ryan
Emily R Schultz
Brian W Raden
Che-Chung Tsai
Faculty of Public Health · GBUniversity of Washington · US

Funding

CELLULAR HOMOLOGS IN A NEW SIMIAN GAMMAHERPESVIRUSR01RR013154 · NCRR · UNIVERSITY OF WASHINGTON · PI ROSE, TIMOTHY M · 1997 to 2004
$1.9M
Viral Etiology of Kaposi's sarcoma-like TumorsK02AI049275 · NIAID · UNIVERSITY OF WASHINGTON · PI ROSE, TIMOTHY M · 2001 to 2005
$493k
NEW HERPESVIRUS IN A SIMIAN MODEL OF KAPOSI'S SARCOMAR55CA072237 · NCI · UNIVERSITY OF WASHINGTON · PI ROSE, TIMOTHY M · 1996 to 1996
–
NCI NIH HHS R55-CA72237NCRR NIH HHS R01 RR013154NCRR NIH HHS R01-RR13154NIAID NIH HHS K02 AI049275NIAID NIH HHS K02-AI49275
6 · The paper itself

Abstract

We previously identified retroperitoneal fibromatosis-associated herpesvirus (RFHV) as a simian homolog of Kaposi's sarcoma-associated herpesvirus (KSHV) in a fibroproliferative malignancy of macaques that has similarities to Kaposi's sarcoma. In this report, we cloned 4.3 kb of divergent locus B (DL-B) flanking the DNA polymerase gene from two variants of RFHV from different species of macaque with a consensus degenerate hybrid oligonucleotide primer approach. Within the DL-B region of RFHV, viral homologs of the cellular interleukin-6, dihydrofolate reductase, and thymidylate synthase genes were identified, along with a homolog of the gammaherpesvirus open reading frame (ORF) 10. In addition, a homolog of the KSHV ORF K3, the modulator of immune recognition-1, was identified. Our data show a close similarity in sequence conservation, gene content, and genomic structure between RFHV and KSHV which strongly supports the grouping of these viral species within the same RV-1 rhadinovirus lineage and the hypothesis that RFHV is the macaque homolog of KSHV.

Indexed as

Evolution, MolecularRhadinovirusAmino Acid SequenceAnimalsBase SequenceCloning, MolecularDNA-Directed DNA PolymeraseHerpesviridae InfectionsHerpesvirus 8, HumanHumansMacaca mulattaMacaca nemestrinaMolecular Sequence DataMonkey DiseasesPhylogenyRetroperitoneal FibrosisDNA-Directed DNA Polymerase

Identifiers

PMID12692211
PMCPMC153986
OpenAlexW2127798439

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.