SynthesisNeuropsychology review2003
A meta-analysis of structural and functional brain imaging in dementia of the Alzheimer's type: a neuroimaging profile.
Synthesis in Neuropsychology review, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Disentangling in-vivo microstructural changes of white and gray matter in mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis.Brain imaging and behavior · 2023Pooled it
- Systematic Review of Different Neuroimaging Correlates in Mild Cognitive Impairment and Alzheimer's Disease.Clinical neuroradiology · 2021Pooled it
- Brain alterations in children/adolescents with ADHD revisited: A neuroimaging meta-analysis of 96 structural and functional studies.Neuroscience and biobehavioral reviews · 2019Pooled it
- Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients.NeuroImage · 2009Pooled it
- Meta-analysis of functional neuroimaging data: current and future directions.Social cognitive and affective neuroscience · 2007Pooled it
- Shared genetic architecture between Alzheimer's disease and brain morphology.Alzheimer's research & therapy · 2026Article
- Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Machine learning based on event-related oscillations of working memory differentiates between preclinical Alzheimer's disease and normal aging.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Cognitive and cerebral phenotypes of neurocognitive disorders due to alcohol or Alzheimer's disease.Brain communications · 2025Article
- Investigating the synergistic effects of hormone replacement therapy, apolipoprotein E and age on brain health in the UK Biobank.Human brain mapping · 2024Article
- Odor Identification Across Time in Mutation Carriers and Non-Carriers in Autosomal-Dominant Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Predicting Four-Year's Alzheimer's Disease Onset Using Longitudinal Neurocognitive Tests and MRI Data Using Explainable Deep Convolutional Neural Networks.Journal of Alzheimer's disease : JAD · 2024Article
- Genetic basis of anatomical asymmetry and aberrant dynamic functional networks in Alzheimer's disease.Brain communications · 2024Article
- Characteristics of Cognitive Function Changes and Related Factors in Individuals With Cognitive Impairment During the Pandemic of COVID-19: A Retrospective Chart Review Study.Psychiatry investigation · 2023Article
- A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan.Cell stem cell · 2022Article
- Progressive structural and covariance connectivity abnormalities in patients with Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Robust EEG Based Biomarkers to Detect Alzheimer's Disease.Brain sciences · 2021Article
- Impaired Expression of GABA Signaling Components in the Alzheimer's Disease Middle Temporal Gyrus.International journal of molecular sciences · 2020Article
- Replicable brain signatures of emotional bias and memory based on diffusion kurtosis imaging of white matter tracts.Human brain mapping · 2020Article
- Correlation Between the Wechsler Adult Intelligence Scale- 3Frontiers in human neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a quantitative review of the imaging literature using meta-analytic methodology to characterize further the magnitude of hippocampal deficit in probable Alzheimer's disease (AD) and to determine whether other neuroanatomic structures in AD can better discriminate the disease from normal aging. Additionally, we parceled the discriminability of neuroanatomic structures by duration of disease to determine those structures most sensitive to AD in its early and late stages. One hundred twenty-one studies published between 1984 and 2000 met criteria for inclusion in the present analysis. In total, structural (i.e., CT and MRI) and functional (i.e., SPECT and PET) neuroimaging results from 3511 patients with AD, and 1632 normal healthy controls were recorded across meta-analyses. Our results include neuroimaging profiles for both early onset and longer duration patients with AD. In sum, these profiles yield a signature of diagnostic markers in both cortical and subcortical neuroanatomic areas. This signature is consistent with the clinical phenomenology of Alzheimer's dementia and should aid in the positive identification of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.