ArticleInternational journal of legal medicine2003
Age estimation based on aspartic acid racemization in elastin from the yellow ligaments.
Article in International journal of legal medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 72 citations in OpenAlex.
- Immunohistological detection of pentosidine in the epiglottis:A contribution to molecular age estimation.International journal of legal medicine · 2026Article
- Immunohistochemical localization of D-β-aspartic acid and periostin in benign parotid gland tumors.Histology and histopathology · 2026Article
- Mammalian Tolerance to Amino Acid Heterochirality.Chembiochem : a European journal of chemical biology · 2025Review
- Molecular age estimation based on posttranslational protein modifications in bone: why the type of bone matters.International journal of legal medicine · 2023Article
- Immunohistochemical localization of d-Laryngoscope investigative otolaryngology · 2022Article
- Predicting Reaction Mechanisms for the Threonine-Residue Stereoinversion Catalyzed by a Dihydrogen Phosphate Ion.ACS omega · 2022Article
- Molecular Mechanisms of Succinimide Formation from Aspartic Acid Residues Catalyzed by Two Water Molecules in the Aqueous Phase.International journal of molecular sciences · 2021Article
- Simultaneous and Rapid Detection of Multiple Epimers and Isomers of Aspartyl Residues in Lens Proteins Using an LC-MS-MRM Method.ACS omega · 2020Article
- Age estimation based on different molecular clocks in several tissues and a multivariate approach: an explorative study.International journal of legal medicine · 2020Article
- Computational Studies on Water-Catalyzed Mechanisms for Stereoinversion of Glutarimide Intermediates Formed from Glutamic Acid Residues in Aqueous Phase.International journal of molecular sciences · 2019Article
- Age estimation based on aspartic acid racemization in dentine: what about caries-affected teeth?International journal of legal medicine · 2018Article
- D-β-aspartyl residue exhibiting uncommon high resistance to spontaneous peptide bond cleavage.Scientific reports · 2016Article
- Age estimation based on aspartic acid racemization in human sclera.International journal of legal medicine · 2016Article
- Biophysical chemistry of the ageing eye lens.Biophysical reviews · 2015Review
- Estimation of age at death based on aspartic acid racemization in elastic cartilage of the epiglottis.International journal of legal medicine · 2014Article
- Kinetics of isomerization and inversion of aspartate 58 of αA-crystallin peptide mimics under physiological conditions.PloS one · 2013Article
- A rapid, comprehensive liquid chromatography-mass spectrometry (LC-MS)-based survey of the Asp isomers in crystallins from human cataract lenses.The Journal of biological chemistry · 2012Article
- Co-localisation of advanced glycation end products and D-β-aspartic acid-containing proteins in gelatinous drop-like corneal dystrophy.The British journal of ophthalmology · 2012Article
- Age estimation based on a combined arteriosclerotic index.International journal of legal medicine · 2012Article
- Aspartic acid racemisation in purified elastin from arteries as basis for age estimation.International journal of legal medicine · 2010Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The yellow ligaments of the spine are characterized by an exceptionally high content of elastin, a protein with a proved longevity in several human tissues. This unique biochemical composition suggested a suitability of yellow ligaments for age estimation based on aspartic acid racemization (AAR), which was tested by determination of AAR in total tissue specimens and in purified elastin from yellow ligaments of individuals of known age. AAR was found to increase with age in both sample sets. The purified elastin samples exhibited a much faster kinetics than the total tissue, with ca. 3.7-4.6-fold higher apparent rates. The relationship between AAR and age was much closer in the purified elastin samples ( r=0.96-0.99) and it can therefore be used as a basis for biochemical age estimation. The analysis of total tissue samples cannot be recommended since the AAR values can be strongly influenced even by slight, histologically non-detectable variations in the collagen content. Age estimation based on AAR in purified elastin from yellow ligaments may be a valuable additional tool in the identification of unidentified cadavers, especially in cases where other methods cannot be applied (e.g. no available teeth, body parts).
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