ArticlePflugers Archiv : European journal of physiology2003
Localization of Ca2+ -activated big-conductance K+ channels in rabbit distal colon.
Article in Pflugers Archiv : European journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Potassium channels in intestinal epithelial cells and their pharmacological modulation: a systematic review.American journal of physiology. Cell physiology · 2021Pooled it
- Aldosterone up-regulates basolateral NaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Colonic Potassium Absorption and Secretion in Health and Disease.Comprehensive Physiology · 2018Review
- Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Role of the BK channel (KCa1.1) during activation of electrogenic K+ secretion in guinea pig distal colon.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- The secretory KCa1.1 channel localises to crypts of distal mouse colon: functional and molecular evidence.Pflugers Archiv : European journal of physiology · 2011Article
- Colonic potassium handling.Pflugers Archiv : European journal of physiology · 2010Review
- Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Molecular investigations of BK(Ca) channels and the modulatory beta-subunits in porcine basilar and middle cerebral arteries.Journal of molecular histology · 2009Article
- Aldosterone increases KCa1.1 (BK) channel-mediated colonic K+ secretion.The Journal of physiology · 2008Article
- Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4.The Journal of physiology · 2007Article
- Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium.Naunyn-Schmiedeberg's archives of pharmacology · 2005Article
- Pathways for K+ efflux in isolated surface and crypt colonic cells. Activation by calcium.The Journal of membrane biology · 2005Article
- Molecular basis of potassium channels in pancreatic duct epithelial cells.Channels (Austin, Tex.)Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Big-conductance Ca(2+)-activated K(+) channels (BK channels) may play an important role in the regulation of epithelial salt and water transport, but little is known about the expression level and the precise localization of BK channels in epithelia. The aim of the present study was to quantify and localize the BK channels in the distal colon epithelium by iberiotoxin (IbTX) binding using the radiolabeled iberiotoxin analogue (125)I-IbTX-D19Y/Y36F, by autoradiography and by immunohistochemical studies. The results showed that the surface cells, responsible for Na(+) absorption, contained a high number of BK channels, whereas the abundance of the channels in the Cl(-)-secreting crypt cells was very low or absent. Surprisingly, the (125)I-IbTX-D19Y/Y36F binding and immunohistochemical studies showed expression of BK channels in the apical as well as in the basolateral membranes of the surface cells. In conclusion, the significant and distinct expression of BK channels in epithelia, combined with their strict regulation, indicate that these channels may play an important role in the overall regulation of salt and water transport.
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