ArticleSexually transmitted infections2003
Comparison of STD prevalences in the Mwanza, Rakai, and Masaka trial populations: the role of selection bias and diagnostic errors.
Article in Sexually transmitted infections, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Low prevalence of cervical infections in women with vaginal discharge in west Africa: implications for syndromic management.Sexually transmitted infections · 2004Trial
- Prevalence and incidence estimates for syphilis, chlamydia, gonorrhea, and congenital syphilis in Colombia, 1995-2016.Revista panamericana de salud publica = Pan American journal of public health · 2018Article
- Article
- Estimating prevalence trends in adult gonorrhoea and syphilis in low- and middle-income countries with the Spectrum-STI model: results for Zimbabwe and Morocco from 1995 to 2016.Sexually transmitted infections · 2017Article
- Trends in Adult Chlamydia and Gonorrhea Prevalence, Incidence and Urethral Discharge Case Reporting in Morocco over 1995-2015-Estimates Using the Spectrum-Sexually Transmitted Infection Model.Sexually transmitted diseases · 2017Article
- Very low sensitivity of wet mount microscopy compared to PCR against culture in the diagnosis of vaginal trichomoniasis in Uganda: a cross sectional study.BMC research notes · 2017Article
- High prevalence of stigma-related abuse among a sample of men who have sex with men in Tanzania: implications for HIV prevention.AIDS care · 2015Article
- Rush to judgment: the STI-treatment trials and HIV in sub-Saharan Africa.Journal of the International AIDS Society · 2015Article
- High HIV seroprevalence, rectal STIs and risky sexual behaviour in men who have sex with men in Dar es Salaam and Tanga, Tanzania.BMJ open · 2014Article
- Incidence and correlates of Chlamydia trachomatis infection in a high-risk cohort of Kenyan women.Sexually transmitted diseases · 2013Article
- Treatment of sexually transmitted infections for HIV prevention: end of the road or new beginning?AIDS (London, England) · 2010Article
- A Bayesian approach to uncertainty analysis of sexually transmitted infection models.Sexually transmitted infections · 2010Article
- Prevalence of genital Chlamydia and gonococcal infections in at risk women in the kumasi metropolis, ghana.Ghana medical journal · 2010Article
- Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa.PloS one · 2008Article
- Cost effectiveness analysis of strategies to combat HIV/AIDS in developing countries.BMJ (Clinical research ed.) · 2005Article
- Sentinel surveillance of sexually transmitted infections in South Africa: a review.Sexually transmitted infections · 2005Review
- Efforts to Control Sexually Transmitted Infections As a Means to Limit HIV Transmission: What Is the Evidence?Current infectious disease reports · 2005Article
- Efforts to control sexually transmitted infections as a means to limit HIV transmission: what is the evidence?Current HIV/AIDS reports · 2004Review
- Psychosocial impact of serological diagnosis of herpes simplex virus type 2: a qualitative assessment.Sexually transmitted infections · 2003Article
- Trends in adult chlamydia and gonorrhoea prevalence, incidence and urethral discharge case reporting in Mongolia from 1995 to 2016 - estimates using the Spectrum-STI model.Western Pacific surveillance and response journal : WPSARArticle
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess bias in estimates of STD prevalence in population based surveys resulting from diagnostic error and selection bias. To evaluate the effects of such biases on STD prevalence estimates from three community randomised trials of STD treatment for HIV prevention in Masaka and Rakai, Uganda and Mwanza, Tanzania.
methodsAge and sex stratified prevalences of gonorrhoea, chlamydia, syphilis, HSV-2 infection, and trichomoniasis observed at baseline in the three trials were adjusted for sensitivity and specificity of diagnostic tests and for sample selection criteria.
resultsSTD prevalences were underestimated in all three populations because of diagnostic errors and selection bias. After adjustment, gonorrhoea prevalence was higher in men and women in Mwanza (2.8% and 2.3%) compared to Rakai (1.1% and 1.9%) and Masaka (0.9% and 1.8%). Chlamydia prevalence was higher in women in Mwanza (13.0%) compared to Rakai (3.2%) and Masaka (1.6%) but similar in men (2.3% in Mwanza, 2.7% in Rakai, and 2.2% in Masaka). Prevalence of trichomoniasis was higher in women in Mwanza compared to women in Rakai (41.9% versus 30.8%). Herpes simplex virus type 2 (HSV-2) seroprevalence and prevalence of serological syphilis (TPHA+/RPR+) were similar in the three populations but the prevalence of high titre syphilis (TPHA+/RPR >/=1:8) in men and women was higher in Mwanza (5.6% and 6.3%) than in Rakai (2.3% and 1.4%) and Masaka (1.2% and 0.7%).
conclusionsLimited sensitivity of diagnostic and screening tests led to underestimation of STD prevalence in all three trials but especially in Mwanza. Adjusted prevalences of curable STD were higher in Mwanza than in Rakai and Masaka.
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