ArticleJournal of assisted reproduction and genetics2003
Higher degree of chromosome mosaicism in preimplantation embryos from carriers of robertsonian translocation t(13;14) in comparison with embryos from karyotypically normal IVF patients.
Article in Journal of assisted reproduction and genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed, 79 citations in OpenAlex.
- Preimplantation genetic diagnosis for couples with a Robertsonian translocation: practical information for genetic counseling.Journal of assisted reproduction and genetics · 2012Article
- Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
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5 authors at 1 institution in 1 country.
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Abstract
purposeTo compare the frequency and the degree of mosaicism in human embryos from Robertsonian translocation (RT) t(13;14) carriers, with embryos from karyotypically normal IVF patients
methodsFISH analysis of embryos from PGD cycles for RT t(13;14), with probes for chromosomes 13, 14, and 18 (Group I) and of embryos from karyotypically normal IVF patients with probes for chromosomes 13, 18, 21, X, and Y (Group II).
resultsThe incidence of abnormal mosaic embryos was significantly higher in group I (38/51) as compared with group II (6/45) (chi2: P < 0.01). Furthermore, in group I the percentage of diploid cells per embryo was lower for chromosome 13 and 14 in comparison with 18, while in group II no differences were observed between the five chromosomes analyzed.
conclusionsRT induces a high frequency of mosaicism specifically for the chromosomes implicated in the translocation; the analysis by FISH of two blastomeres is strongly recommended for these patients
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