ArticleAmerican journal of human genetics2003
A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 218 citations in OpenAlex.
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Pooled it
- A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs.Molecular psychiatry · 2006Trial
- Prenatal stress selectively enhances locomotor hyperactivity in male mice with embryonic loss ofFrontiers in psychiatry · 2026Article
- A Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents-Offspring Trios.Frontiers in genetics · 2022Article
- Analysis of shared homozygosity regions in Saudi siblings with attention deficit hyperactivity disorder.Psychiatric genetics · 2017Article
- Genetics in child and adolescent psychiatry: methodological advances and conceptual issues.European child & adolescent psychiatry · 2015Review
- Attention Deficit Hyperactivity Disorder in the Light of the Epigenetic Paradigm.Frontiers in psychiatry · 2015Review
- The neurobiological link between OCD and ADHD.Attention deficit and hyperactivity disorders · 2014Review
- Nutrition, immunological mechanisms and dietary immunomodulation in ADHD.European child & adolescent psychiatry · 2014Review
- Association of the KCNJ5 gene with Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder.Genes, brain, and behavior · 2014Article
- Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample.Molecular psychiatry · 2014Article
- Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.Genes, brain, and behavior · 2014Article
- Genome-Wide Studies of Specific Language Impairment.Current behavioral neuroscience reports · 2014Review
- Article
- Attention deficit hyperactivity disorder.Current topics in behavioral neurosciences · 2014Review
- The genetics of attention deficit/hyperactivity disorder in adults, a review.Molecular psychiatry · 2012Review
- The genetics of reading disabilities: from phenotypes to candidate genes.Frontiers in psychology · 2012Article
- GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice.Nature medicine · 2011Article
- Modeling hyperactivity: of mice and men.Nature medicine · 2011Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Attention-deficit/hyperactivity disorder (ADHD [MIM 143465]) is a common, highly heritable neurobehavioral disorder of childhood onset, characterized by hyperactivity, impulsivity, and/or inattention. As part of an ongoing study of the genetic etiology of ADHD, we have performed a genomewide linkage scan in 204 nuclear families comprising 853 individuals and 270 affected sibling pairs (ASPs). Previously, we reported genomewide linkage analysis of a "first wave" of these families composed of 126 ASPs. A follow-up investigation of one region on 16p yielded significant linkage in an extended sample. The current study extends the original sample of 126 ASPs to 270 ASPs and provides linkage analyses of the entire sample, using polymorphic microsatellite markers that define an approximately 10-cM map across the genome. Maximum LOD score (MLS) analysis identified suggestive linkage for 17p11 (MLS=2.98) and four nominal regions with MLS values >1.0, including 5p13, 6q14, 11q25, and 20q13. These data, taken together with the fine mapping on 16p13, suggest two regions as highly likely to harbor risk genes for ADHD: 16p13 and 17p11. Interestingly, both regions, as well as 5p13, have been highlighted in genomewide scans for autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.