ReviewNeurogenetics2003
Genetic animal models of anxiety.
Review in Neurogenetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Central role of regular firing neurons of centrolateral amygdala in affective behaviors.iScience · 2025Article
- Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease.Molecular brain · 2022Article
- Light-Dark Open Field (LDOF): A novel task for sensitive assessment of anxiety.Journal of neuroscience methods · 2021Article
- Understanding stress: Insights from rodent models.Current research in neurobiology · 2021Review
- Effects ofBrain and behavior · 2017Article
- Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice.Molecular psychiatry · 2017Article
- Age-dependent differential regulation of anxiety- and depression-related behaviors by neurabin and spinophilin.PloS one · 2017Article
- Affective and cognitive behavior in the alpha-galactosidase A deficient mouse model of Fabry disease.PloS one · 2017Article
- Optogenetic insights on the relationship between anxiety-related behaviors and social deficits.Frontiers in behavioral neuroscience · 2014Review
- Serotonin 5-HT1A receptors as targets for agents to treat psychiatric disorders: rationale and current status of research.CNS drugs · 2013Review
- A myelin gene causative of a catatonia-depression syndrome upon aging.EMBO molecular medicine · 2012Article
- Health effects of ingestion of mercury-polluted urban soil: an animal experiment.Environmental geochemistry and health · 2012Article
- The age of anxiety: role of animal models of anxiolytic action in drug discovery.British journal of pharmacology · 2011Review
- The clinical implications of mouse models of enhanced anxiety.Future neurology · 2011Article
- Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice.Molecular brain · 2011Article
- Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?Genes, brain, and behavior · 2010Article
- Measuring anxiety- and locomotion-related behaviours in mice: a new way of using old tests.Psychopharmacology · 2010Article
- Serotonin transporter polymorphisms and panic disorder.Genome medicine · 2010Article
- Prevalence of obsessive-compulsive disorder in Turkish university students and assessment of associated factors.BMC psychiatry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The focus of this review is on progress achieved in identifying specific genes conferring risk for anxiety disorders through the use of genetic animal models. We discuss gene-finding studies as well as those manipulating a candidate gene. Both human and animal studies thus far support the genetic complexity of anxiety. Clinical manifestations of these diseases are likely related to multiple genes. While different anxiety disorders and anxiety-related traits all appear to be genetically influenced, it has been difficult to ascertain genetic influences in common. Mouse studies have provisionally mapped several loci harboring genes that affect anxiety-related behavior. The growing array of mutant mice is providing valuable information about how genes and environment interact to affect anxious behavior via multiple neuropharmacological pathways. Classical genetic methods such as artificial selection of rodents for high or low anxiety are being employed. Expression array technologies have as yet not been employed, but can be expected to implicate novel candidates and neurobiological pathways.
Indexed as
Identifiers
12687420What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.