ReviewPflugers Archiv : European journal of physiology2003
Heartburn: cardiac potassium channels involved in parietal cell acid secretion.
Review in Pflugers Archiv : European journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- Kv7 Channels and Excitability Disorders.Handbook of experimental pharmacology · 2021Article
- Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1.Pflugers Archiv : European journal of physiology · 2015Article
- SLO3 K+ channels control calcium entry through CATSPER channels in sperm.The Journal of biological chemistry · 2014Article
- KCNE Regulation of K(+) Channel Trafficking - a Sisyphean Task?Frontiers in physiology · 2012Article
- AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells.American journal of physiology. Renal physiology · 2010Article
- KCNQ1 loss-of-function mutation impairs gastric acid secretion in mice.Molecular biology reports · 2010Article
- KCNQ1 is the luminal K+ recycling channel during stimulation of gastric acid secretion.The Journal of physiology · 2009Article
- Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.The Journal of physiology · 2004Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrochloric acid is produced in parietal cells of the gastric glands by an H(+)/K(+)-ATPase. This proton pump couples the outwards movement of H(+) to the inwards movement of K(+) thus requiring the presence of luminal K(+) to operate. To maintain the activity of the pump, K(+) recirculates over the apical membrane via conductive pathways, the molecular nature of which has been identified in the past few years. This review gives a short overview about the recent advances in the understanding of the role of K(+) channels in the process of parietal cell H(+) secretion and focuses on the identification of KCNQ1/KCNE2 K(+) channel as the molecular correlate of the parietal cell apical potassium conductance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.