ArticlePflugers Archiv : European journal of physiology2003
Aldosterone stimulates surface expression of NHE3 in renal proximal brush borders.
Article in Pflugers Archiv : European journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 42 citations in OpenAlex.
- SECS, drugs, and Rac1&Rho: regulation of EnNaC in vascular endothelial cells.Pflugers Archiv : European journal of physiology · 2025Article
- Aldosterone: Renal Action and Physiological Effects.Comprehensive Physiology · 2023Article
- Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney.International journal of endocrinology · 2017Article
- Urinary Exosomes and Their Cargo: Potential Biomarkers for Mineralocorticoid Arterial Hypertension?Frontiers in endocrinology · 2017Review
- Sex-dependent expression of water channel AQP1 along the rat nephron.American journal of physiology. Renal physiology · 2015Article
- Molecular mechanisms and regulation of urinary acidification.Comprehensive Physiology · 2014Review
- Physiology and pathophysiology of SLC12A1/2 transporters.Pflugers Archiv : European journal of physiology · 2014Review
- Combined Effects of PPAR γ Agonists and Epidermal Growth Factor Receptor Inhibitors in Human Proximal Tubule Cells.PPAR research · 2013Article
- Aldosterone stimulates vacuolar H(+)-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway.American journal of physiology. Cell physiology · 2011Article
- Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells.Molecular and cellular biochemistry · 2008Article
- The expanding role of aldosterone in the regulation of body Na content.Pflugers Archiv : European journal of physiology · 2003Review
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5 authors at 4 institutions in 2 countries.
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Abstract
The mineralocorticoid aldosterone is one of the major regulators of extracellular volume and blood pressure. It acts by enhancing Na(+) reabsorption across tight epithelia such as renal collecting ducts and colon. In addition, it has been shown that aldosterone stimulates NaCl and volume reabsorption in renal proximal tubules by an unknown mechanism. To test the hypothesis that the application of aldosterone results in greater activity of the apical Na(+)/H(+) exchanger-3 (NHE3), we investigated the effect of aldosterone on amiloride-sensitive, proximal tubular volume reabsorption and proximal tubular NHE3 abundance in adrenalectomized rats. Aldosterone at physiological concentrations (dosage 36 microg/100 g b.w. per day) increased NHE3-dependent proximal tubular volume reabsorption and the abundance of NHE3 in brush borders without changing the total amount of NHE3 in cortical homogenates. These results indicate that renal proximal tubular NHE3 is a target for aldosterone-mediated regulation resulting in increased Na(+) reabsorption and thus extracellular volume and blood pressure. Further studies are required to determine the precise mechanism of action, especially whether the action of aldosterone on proximal tubular function is direct or indirect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.