ReviewMedical microbiology and immunology2003
Pathogenesis of Adamantiades-Behçet's disease.
Review in Medical microbiology and immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Association betweenThe Journal of international medical research · 2021Pooled it
- Trial
- Altered polyunsaturated fatty acids and oxylipins profile in Behçet's disease.The Korean journal of internal medicine · 2025Article
- Epidemiology and treatment of Adamantiades-Behçet's disease in Germany: A healthcare claims database study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- The oral microbiome and oral and upper gastrointestinal diseases.Journal of oral microbiology · 2024Review
- Identification of the immune-related biomarkers in Behcet's disease by plasma proteomic analysis.Arthritis research & therapy · 2023Article
- Impact of Climate Change on Eye Diseases and Associated Economical Costs.International journal of environmental research and public health · 2021Review
- Calprotectin in rheumatic diseases.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Immunopathogenesis of ocular Behçet's disease.Journal of immunology research · 2014Review
- A New Diagnostic Way for Behcet's Disease: Skin Prick with Self-Saliva.Genetics research international · 2014Review
- Proliferative vitreoretinopathy may be a risk factor in combined macular hole retinal detachment cases.Retina (Philadelphia, Pa.) · 2013Article
- Successful treatment for a giant coronary saccular aneurysm complicated with myocardial infarction in a patient with Behcet's disease: Case report.Journal of cardiology cases · 2012Article
- SUMO4 C438T polymorphism is associated with papulopustular skin lesion in Korean patients with Behçet's disease.Rheumatology international · 2012Article
- [Epidemiology of ocular involvement in Adamantiades-Behçets disease].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2012Article
- Colchicine modulates oxidative stress in serum and neutrophil of patients with Behçet disease through regulation of Ca²⁺ release and antioxidant system.The Journal of membrane biology · 2011Article
- Expression of Pro-inflammatory Protein S100A12 (EN-RAGE) in Behçet's Disease and Its Association with Disease Activity: A Pilot Study.Annals of dermatology · 2011Article
- Skin prick test with self-saliva in patients with oral aphthoses: a diagnostic pathergy for Behcet's disease and recurrent aphthosis.Inflammation & allergy drug targets · 2011Article
- Behçet's disease (Adamantiades-Behçet's disease).Clinical & developmental immunology · 2011Review
- Etiopathogenesis of Behçet's disease with emphasis on the role of immunological aberrations.Clinical rheumatology · 2010Review
- Comorbidities of hidradenitis suppurativa (acne inversa).Dermato-endocrinology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aetiology of Adamantiades-Behçet's disease remains unknown and its pathogenesis is not fully understood. Linked intrinsic and extrinsic factors are thought to contribute to the development of the disease, which probably occurs by environmental triggering of a genetically determined disorder. Transmission is solely vertical, indicating that the disease is not contagious. Genetic factors have been investigated and a significant link of HLA-B51, especially of HLA-B5101, has been identified. However, none of the functional correlates of the disease appear to be restricted by HLA-B51. Recently, the role of the genes encoding TNF, Tap proteins and MICA has been emphasised. Extrinsic pathogenetic candidates have been identified, including bacterial ( Streptococcus sanguis, Mycoplasma fermentas) and viral (human herpes virus) antigens and environmental pollution, which may cross-react with oral mucosal antigens and induce immunological mechanisms. A common factor linking some of the possible pathogenetic agents is extrinsically induced tissue stress or heat shock proteins, which react with host tissues and elicit significant Th1 cell responses. Neutrophils may also play a role in the pathogenesis of the disease, as they are attracted by macrophages and activated endothelial cells, which release cytokines and chemokines (especially IL-8) at the site of the lesions, and thus contribute to tissue damage and self maintenance of inflammation. Endothelial activation leading to a chronic local inflammation process together with platelet and serum factors enhance coagulation and thrombosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.