ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Regulation of spike initiation and propagation in an Aplysia sensory neuron: gating-in via central depolarization.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Synaptic input and temperature influence sensory coding in a mechanoreceptor.Frontiers in cellular neuroscience · 2023Article
- Different microcircuit responses to comparable input from one versus both copies of an identified projection neuron.The Journal of experimental biology · 2020Article
- Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model,The Journal of biological chemistry · 2017Article
- State-dependent sensorimotor gating in a rhythmic motor system.Journal of neurophysiology · 2017Article
- Activity-dependent increases in [CaJournal of neurophysiology · 2017Article
- The Site of Spontaneous Ectopic Spike Initiation Facilitates Signal Integration in a Sensory Neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Repetition priming-induced changes in sensorimotor transmission.Journal of neurophysiology · 2016Article
- Motor neuronal activity varies least among individuals when it matters most for behavior.Journal of neurophysiology · 2015Article
- Coordination of distinct motor structures through remote axonal coupling of projection interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.Progress in neurobiology · 2011Review
- Effect of presynaptic membrane potential on electrical vs. chemical synaptic transmission.Journal of neurophysiology · 2011Article
- Neural circuit flexibility in a small sensorimotor system.Current opinion in neurobiology · 2011Review
- Effect of holding potential on the dynamics of homosynaptic facilitation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Composite modulatory feedforward loop contributes to the establishment of a network state.Journal of neurophysiology · 2010Article
- Role of tonic inhibition in associative reward conditioning in lymnaea.Frontiers in behavioral neuroscience · 2010Article
- Distinct inhibitory neurons exert temporally specific control over activity of a motoneuron receiving concurrent excitation and inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Regulation of motor patterns by the central spike-initiation zone of a sensory neuron.The European journal of neuroscience · 2009Article
- Two distinct mechanisms mediate potentiating effects of depolarization on synaptic transmission.Journal of neurophysiology · 2009Article
- Comparative neurobiology of feeding in the opisthobranch sea slug, Aplysia, and the pulmonate snail, Helisoma: evolutionary considerations.Brain, behavior and evolution · 2009Review
- Selective spike propagation in the central processes of an invertebrate neuron.Journal of neurophysiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Afferent transmission can be regulated (or gated) so that responses to peripheral stimuli are adjusted to make them appropriate for the ongoing phase of a motor program. Here, we characterize a gating mechanism that involves regulation of spike propagation in Aplysia mechanoafferent B21. B21 is striking in that afferent transmission to the motor neuron B8 does not occur when B21 is at resting membrane potential. Our data suggest that this results from the fact that spikes are not actively propagated to the lateral process of B21 (the primary contact with B8). When B21 is peripherally activated at its resting potential, electrotonic potentials in the lateral process are on average 11 mV. In contrast, mechanoafferent activity is transmitted to B8 when B21 is centrally depolarized via current injection. Our data suggest that central depolarization relieves propagation failure. Full-size spikes are recorded in the lateral process when B21 is depolarized and then peripherally activated. Moreover, changes in membrane potential in the lateral process affect spike amplitude, even when the somatic membrane potential is virtually unchanged. During motor programs, both the lateral process and the soma of B21 are phasically depolarized via synaptic input. These depolarizations are sufficient to convert subthreshold potentials to full-size spikes in the lateral process. Thus, our data strongly suggest that afferent transmission from B21 to B8 is, at least in part, regulated via synaptic control of spike initiation in the lateral process. Consequences of this control for compartmentalization in B21 are discussed, as are specific consequences for feeding behavior.
Indexed as
Identifiers
12684479PMC6742086W2162156626What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.