ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Exocytosis at the ribbon synapse of retinal bipolar cells studied in patches of presynaptic membrane.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- IK Channel Confers Fine-tuning of Rod Bipolar Cell Excitation and Synaptic Transmission in the Retina.Function (Oxford, England) · 2025Article
- Direct Observation of Vesicle Transport on the Synaptic Ribbon Provides Evidence That Vesicles Are Mobilized and Prepared Rapidly for Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Two Pools of Vesicles Associated with Synaptic Ribbons Are Molecularly Prepared for Release.Biophysical journal · 2017Article
- Calcium-activated BKThe Journal of physiology · 2017Article
- Visualizing synaptic vesicle turnover and pool refilling driven by calcium nanodomains at presynaptic active zones of ribbon synapses.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Amperometric resolution of a prespike stammer and evoked phases of fast release from retinal bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Endophilin drives the fast mode of vesicle retrieval in a ribbon synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Characterisation of bipolar cell synaptic transmission in goldfish retina using paired recordings.The Journal of physiology · 2010Article
- The role of ribbons at sensory synapses.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2009Review
- Differential effects of charybdotoxin on the activity of retinal ganglion cells in the dark- and light-adapted mouse retina.Vision research · 2009Article
- Synaptic regulation of the light-dependent oscillatory currents in starburst amacrine cells of the mouse retina.Journal of neurophysiology · 2008Article
- Measurements of membrane patch capacitance using a software-based lock-in system.Pflugers Archiv : European journal of physiology · 2007Article
- Diurnal changes in exocytosis and the number of synaptic ribbons at active zones of an ON-type bipolar cell terminal.Journal of neurophysiology · 2006Article
- Modulation of Ca(2+)-activated K+ currents and Ca(2+)-dependent action potentials by exocytosis in goldfish bipolar cell terminals.The Journal of physiology · 2006Article
- Frequency selectivity of synaptic exocytosis in frog saccular hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Synaptic transmission at retinal ribbon synapses.Progress in retinal and eye research · 2005Review
- Large-conductance calcium-activated potassium channels facilitate transmitter release in salamander rod synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of exocytic sites and ion channels in the synaptic terminal of retinal bipolar cells was investigated by measuring capacitance and conductance changes in cell-attached patches of presynaptic membrane. Patch depolarization evoked capacitance and conductance increases that were inhibited by blocking Ca(2+) influx or loading the terminal with EGTA. The increase in capacitance declined as the depolarization approached the reversal potential for Ca(2+), indicating that it was a result of Ca(2+)-dependent exocytosis. The conductance increase was caused by K(Ca) channels that were also activated by Ca(2+) influx. Two observations indicated that sites of exocytosis and endocytosis colocalized with clusters of Ca(2+) channels and K(Ca) channels; the initial rate of exocytosis was correlated with the activation of K(Ca) channels, and exocytosis did not occur in the 41% of patches lacking this conductance. Electron microscopy demonstrated that there were approximately 16 vesicles docked to the plasma membrane at each active zone marked by a ribbon, but vesicles were also attached to the rest of the membrane at a density of 1.5/microm(2). The density of ribbons was 0.10 +/- 0.02/microm(2), predicting that approximately 43% of cell-attached patches would lack an active zone. The density of Ca(2+) channel clusters assayed by capacitance and conductance responses was therefore similar to the density of ribbons. These results are consistent with the idea that Ca(2+) channel clusters were colocalized with ribbons but do not exclude the possibility that calcium channels also occurred at other sites. The wide distribution of vesicles docked to the plasma membrane suggests that exocytosis might also be triggered by the spread of Ca(2+) from Ca(2+) channel clusters.
Indexed as
Identifiers
12684456PMC6742116W2151022750What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.