ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Electrophysiological characterization of voltage-gated currents in defined taste cell types of mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 137 citations in OpenAlex.
- Receptors and signaling for sour and salty: the ionic taste qualities.Chemical senses · 2025Review
- Give-and-take of gustation: the interplay between gustatory neurons and taste buds.Chemical senses · 2024Review
- Article
- Effects of temperature on action potentials and ion conductances in type II taste-bud cells.American journal of physiology. Cell physiology · 2023Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Taste Cells of the Type III Employ CASR to Maintain Steady Serotonin Exocytosis at Variable CaCells · 2022Article
- The Cellular and Molecular Basis of Sour Taste.Annual review of physiology · 2022Review
- Taste Receptor Signaling.Handbook of experimental pharmacology · 2022Article
- "Tripartite Synapses" in Taste Buds: A Role for Type I Glial-like Taste Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Functional expression of TMEM16A in taste bud cells.The Journal of physiology · 2021Article
- GAD65Cre Drives Reporter Expression in Multiple Taste Cell Types.Chemical senses · 2021Article
- Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation.Frontiers in human neuroscience · 2021Review
- Charging Up the Periphery: Glial Ionic Regulation in Sensory Perception.Frontiers in cell and developmental biology · 2021Review
- Taste transduction and channel synapses in taste buds.Pflugers Archiv : European journal of physiology · 2021Review
- A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli.PLoS genetics · 2020Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Spilanthol Enhances Sensitivity to Sodium in Mouse Taste Bud Cells.Chemical senses · 2019Article
- Chemical synapses without synaptic vesicles: Purinergic neurotransmission through a CALHM1 channel-mitochondrial signaling complex.Science signaling · 2018Article
- TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Despite extensive immunological characterization of the cells within taste buds, little is known about the functional significance of the different cell types. In this study, we use taste cells isolated from mouse vallate and foliate papillae to characterize voltage-gated currents in the three principal elongate types of taste cells: type I, II, and III. Cell types are identified by using antibodies to external epitopes [antigen H for type I cells, antigen A for type II cells, and neural cell adhesion molecule (NCAM) for type III cells]. In addition, we identify the subset of type II cells that contains alpha-gustducin, a G-protein involved in bitter transduction, by using transgenic mice expressing green fluorescent protein under the control of the gustducin promoter. Our results indicate that antigen H-immunoreactive (-IR) cells and many of the antigen A-IR cells have small voltage-gated inward Na(+) and outward K(+) currents but no voltage-gated Ca(2+) currents. In contrast, a subset of antigen A-IR cells and all NCAM-IR cells have large inward Na(+) and outward K(+) currents as well as voltage-gated Ca(2+) currents. Unexpectedly, all gustducin-expressing cells lacked voltage-gated Ca(2+) currents, suggesting that these cells use mechanisms other than classical synapses to communicate signals to the brain.
Indexed as
Identifiers
12684446PMC6742075W1857132483What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.