Evidence map›Paper›PMID 12684383›Full record

ArticleEukaryotic cell2003

Histone H1 Is required for proper regulation of pyruvate decarboxylase gene expression in Neurospora crassa.

H Diego Folco, Michael Freitag, Ana Ramón, Esteban D Temporini, María E Alvarez, Irene García, Claudio Scazzocchio, Eric U Selker, Alberto L Rosa

Open access · diamondAbstract read
In one paragraph

Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  7. Physical interaction between VIVID and white collar complex regulates photoadaptation in Neurospora.Proceedings of the National Academy of Sciences of the United States of America · 2010
    Article
  8. Article
  9. PARP is involved in replicative aging in Neurospora crassa.Fungal genetics and biology : FG & B · 2010
    Article
  10. Review
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  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

H Diego FolcoInstituto de Investigación Médica Mercedes y Martín Ferreyra, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5016 Córdoba, Argentina.
Michael Freitag
Ana Ramón
Esteban D Temporini
María E Alvarez
Irene García
Claudio Scazzocchio
Eric U Selker
Alberto L Rosa
Université Paris Cité · FRUniversidad Nacional de Córdoba · ARUniversity of Oregon · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARInstituto de Investigación Médica Mercedes y Martín Ferreyra · AR

Funding

Genetic Aspects of DNA MethylationR37GM035690 · NIGMS · UNIVERSITY OF OREGON · PI SELKER, ERIC U. · 2003 to 2012
$5.2M
GENETIC ASPECTS OF DNA METHYLATIONR01GM035690 · NIGMS · UNIVERSITY OF OREGON · PI SELKER, ERIC U. · 1986 to 2016
$3.3M
IDENTIFICATION OF SIGNALS FOR DE NOVO METHYLATION OF DNAF32CA073123 · NCI · UNIVERSITY OF OREGON · PI FREITAG, MICHAEL · 1997 to 1999
–
NCI NIH HHS CA73123NCI NIH HHS F32 CA073123NIGMS NIH HHS GM35690NIGMS NIH HHS R01 GM035690NIGMS NIH HHS R37 GM035690
6 · The paper itself

Abstract

We show that Neurospora crassa has a single histone H1 gene, hH1, which encodes a typical linker histone with highly basic N- and C-terminal tails and a central globular domain. A green fluorescent protein-tagged histone H1 chimeric protein was localized exclusively to nuclei. Mutation of hH1 by repeat-induced point mutation (RIP) did not result in detectable defects in morphology, DNA methylation, mutagen sensitivity, DNA repair, fertility, RIP, chromosome pairing, or chromosome segregation. Nevertheless, hH1 mutants had mycelial elongation rates that were lower than normal on all tested carbon sources. This slow linear growth phenotype, however, was less evident on medium containing ethanol. The pyruvate decarboxylase gene, cfp, was abnormally derepressed in hH1 mutants on ethanol-containing medium. This derepression was also found when an ectopically integrated fusion of the cfp gene promoter to the reporter gene hph was analyzed. Thus, Neurospora histone H1 is required for the proper regulation of cfp, a gene with a key role in the respiratory-fermentative pathway.

Indexed as

Amino Acid SequenceBase SequenceCell RespirationCell SizeChromosome SegregationDNA MethylationDNA RepairDown-RegulationEthanolGene Expression Regulation, FungalHistonesMolecular Sequence DataMutagensNeurospora crassaPoint MutationPromoter Regions, GeneticEthanolHistonesMutagensPyruvate Decarboxylase

Identifiers

PMID12684383
PMCPMC154839
OpenAlexW2145543625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.