ArticleEukaryotic cell2003
Rapamycin mimics the incompatibility reaction in the fungus Podospora anserina.
Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 102 citations in OpenAlex.
- Article
- Starvation-induced cell fusion and heterokaryosis frequently escape imperfect allorecognition systems in an asexual fungal pathogen.BMC biology · 2021Article
- High-dose rapamycin exerts a temporary impact on T. reesei RUT-C30 through gene trFKBP12.Biotechnology for biofuels · 2021Article
- Hex1, the Major Component of Woronin Bodies, Is Required for Normal Development, Pathogenicity, and Stress Response in the Plant Pathogenic FungusJournal of fungi (Basel, Switzerland) · 2020Article
- Article
- Regulated Forms of Cell Death in Fungi.Frontiers in microbiology · 2017Review
- Overlapping Podospora anserina Transcriptional Responses to Bacterial and Fungal Non Self Indicate a Multilayered Innate Immune Response.Frontiers in microbiology · 2016Article
- Does autophagy mediate age-dependent effect of dietary restriction responses in the filamentous fungus Podospora anserina?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- RNA-seq analyses of gene expression in the microsclerotia of Verticillium dahliae.BMC genomics · 2013Article
- The transcriptional response to nonself in the fungus Podospora anserina.G3 (Bethesda, Md.) · 2013Article
- Functional analysis of the Aspergillus nidulans kinome.PloS one · 2013Article
- Limited vegetative compatibility as a cause of somatic recombination in Trichoderma pseudokoningii.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011Article
- Inactivation of Snt2, a BAH/PHD-containing transcription factor, impairs pathogenicity and increases autophagosome abundance in Fusarium oxysporum.Molecular plant pathology · 2011Article
- A nitrogen response pathway regulates virulence functions in Fusarium oxysporum via the protein kinase TOR and the bZIP protein MeaB.The Plant cell · 2010Article
- Sexual and vegetative compatibility genes in the aspergilli.Studies in mycology · 2007Article
- VIB-1 is required for expression of genes necessary for programmed cell death in Neurospora crassa.Eukaryotic cell · 2006Article
- Role of the Fusarium fujikuroi TOR kinase in nitrogen regulation and secondary metabolism.Eukaryotic cell · 2006Article
- A nonself recognition gene complex in Neurospora crassa.Genetics · 2006Article
- Podospora anserina target of rapamycin.Current genetics · 2006Article
- Comparative analysis of programmed cell death pathways in filamentous fungi.BMC genomics · 2005Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In filamentous fungi, a programmed cell death (PCD) reaction occurs when cells of unlike genotype fuse. This reaction is caused by genetic differences at specific loci termed het loci (for heterokaryon incompatibility). Although several het genes have been characterized, the mechanism of this cell death reaction and its relation to PCD in higher eukaryotes remains largely unknown. In Podospora anserina, genes induced during the cell death reaction triggered by the het-R het-V interaction have been identified and termed idi genes. Herein, we describe the functional characterization of one idi gene (idi-1) and explore the connection between incompatibility and the response to nutrient starvation. We show that IDI-1 is a cell wall protein which localizes at the septum during normal growth. We found that induction of idi-1 and of the other known idi genes is not specific of the incompatibility reaction. The idi genes are induced upon nitrogen and carbon starvation and by rapamycin, a specific inhibitor of the TOR kinase pathway. The cytological hallmarks of het-R het-V incompatibility (increased septation, vacuolization, coalescence of lipid droplets, induction of autophagy, and cell death) are also observed during rapamycin treatment. Globally the cytological alterations and modifications in gene expression occurring during the incompatibility reaction are similar to those observed during starvation or rapamycin treatment.
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