ArticleEukaryotic cell2003
A circadian oscillator in Aspergillus spp. regulates daily development and gene expression.
Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 79 citations in OpenAlex.
- Identification of Circadian Clock Homologs and Their Rhythmic Expression Differences Among Mating-Type Strains inJournal of fungi (Basel, Switzerland) · 2026Article
- Circadian clock is critical for fungal pathogenesis by regulating zinc starvation response and secondary metabolism.Science advances · 2025Article
- A circadian clock in a nonphotosynthetic prokaryote.Science advances · 2021Article
- Opposite Nuclear Dynamics of Two FRH-Dominated Frequency Proteins Orchestrate Non-Rhythmic Conidiation inCells · 2020Article
- Microbes in the Era of Circadian Medicine.Frontiers in cellular and infection microbiology · 2020Review
- No Evidence That Homologs of Key Circadian Clock Genes Direct Circadian Programs of Development or mRNA Abundance inFrontiers in microbiology · 2020Article
- Review
- Expression of putative circadian clock components in the arbuscular mycorrhizal fungus Rhizoglomus irregulare.Mycorrhiza · 2018Article
- Spontaneous circadian rhythms in a cold-adapted natural isolate of Aureobasidium pullulans.Scientific reports · 2017Article
- Making Time: Conservation of Biological Clocks from Fungi to Animals.Microbiology spectrum · 2017Review
- Genetic Variation and Its Reflection on Posttranslational Modifications in Frequency Clock and Mating Type a-1 Proteins inBioMed research international · 2017Article
- Daily rhythms and enrichment patterns in the transcriptome of the behavior-manipulating parasite Ophiocordyceps kimflemingiae.PloS one · 2017Article
- A Cellular Fusion Cascade Regulated by LaeA Is Required for Sclerotial Development inFrontiers in microbiology · 2017Article
- Natural Variation of the Circadian Clock in Neurospora.Advances in genetics · 2017Review
- Aspergillus fumigatus Photobiology Illuminates the Marked Heterogeneity between Isolates.mBio · 2016Article
- The circadian system as an organizer of metabolism.Fungal genetics and biology : FG & B · 2016Review
- Analysis of Circadian Rhythms in the Basal Filamentous Ascomycete Pyronema confluens.G3 (Bethesda, Md.) · 2015Article
- Fungal photobiology: visible light as a signal for stress, space and time.Current genetics · 2015Review
- A circadian oscillator in the fungus Botrytis cinerea regulates virulence when infecting Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dissecting the mechanisms of the clock in Neurospora.Methods in enzymology · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We have established the presence of a circadian clock in Aspergillus flavus and Aspergillus nidulans by morphological and molecular assays, respectively. In A. flavus, the clock regulates an easily assayable rhythm in the development of sclerotia, which are large survival structures produced by many fungi. This developmental rhythm exhibits all of the principal clock properties. The rhythm is maintained in constant environmental conditions with a period of 33 h at 30 degrees C, it can be entrained by environmental signals, and it is temperature compensated. This endogenous 33-h period is one of the longest natural circadian rhythms reported for any organism, and this likely contributes to some unique responses of the clock to environmental signals. In A. nidulans, no obvious rhythms in development are apparent. However, a free running and entrainable rhythm in the accumulation of gpdA mRNA (encoding glyceraldehyde-3-phosphate dehydrogenase) is observed, suggesting the presence of a circadian clock in this species. We are unable to identify an Aspergillus ortholog of frequency, a gene required for normal circadian rhythmicity in Neurospora crassa. Together, our data indicate the existence of an Aspergillus circadian clock, which has properties that differ from that of the well-described clock of N. crassa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.