ArticleEukaryotic cell2003
Nuclear import of zinc binuclear cluster proteins proceeds through multiple, overlapping transport pathways.
Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- The ß-importin KAP8 (Pse1/Kap121) is required for nuclear import of the cellulase transcriptional regulator XYR1, asexual sporulation and stress resistance in Trichoderma reesei.Molecular microbiology · 2015Article
- Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA.Eukaryotic cell · 2014Article
- Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4.PloS one · 2014Article
- Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein.The Journal of biological chemistry · 2012Article
- Nuclear import by karyopherin-βs: recognition and inhibition.Biochimica et biophysica acta · 2011Review
- The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins.Molecular biology of the cell · 2006Article
- A fungal family of transcriptional regulators: the zinc cluster proteins.Microbiology and molecular biology reviews : MMBR · 2006Review
- Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus.The Journal of cell biology · 2005Article
- New insights into the nuclear localization of retroviral Gag proteins.Nucleus (Austin, Tex.)Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In Aspergillus nidulans, the high transcriptional level of the ethanol utilization pathway genes (alc) is regulated by the specific activator AlcR. Here we have analyzed the mechanism of the nuclear import of AlcR, as well as that of other proteins belonging to the Zn(2)Cys(6) binuclear cluster family. The nuclear localization signal of AlcR maps within the N-terminal 75 amino acid residues and overlaps with its DNA-binding domain. It consists of five clusters rich in basic residues. Four of them are necessary and sufficient for nuclear targeting. The first two basic regions are crucial for both nuclear localization and recognition of AlcR-specific DNA targets. This nuclear localization signal (NLS) motif is recognized by the nuclear transport machinery of Saccharomyces cerevisiae and requires both Ran/Gsp1p activity and specific transport receptors. AlcR can be imported into nuclei via multiple transport pathways mediated by a distinct set of karyopherins composed of Kap104p, Sxm1p, and Nmd5p transport receptors. The two former karyopherins interact with the NLS of AlcR directly. Other Zn binuclear cluster proteins from S. cerevisiae, such as Gal4p and Pdr3p, also appear to be transported to the nuclei in a nonclassical, importin-alpha-independent manner and can share common importin beta receptors.
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