ArticleAmerican journal of physiology. Endocrinology and metabolism2003
Intravenous estrogens increase insulin clearance and action in postmenopausal women.
Article in American journal of physiology. Endocrinology and metabolism, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Combined estrogen replacement therapy on metabolic control in postmenopausal women with diabetes mellitus.The Kaohsiung journal of medical sciences · 2014Pooled it
- Menstrual Dysfunction in Girls From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.The Journal of clinical endocrinology and metabolism · 2018 · on this mapTrial
- Trial
- Timing of Estradiol Treatment After Menopause May Determine Benefit or Harm to Insulin Action.The Journal of clinical endocrinology and metabolism · 2015Trial
- Estrogen or raloxifene during postmenopausal weight loss: adiposity and cardiometabolic outcomes.Obesity (Silver Spring, Md.) · 2014Trial
- Effect of ovarian suppression with gonadotropin-releasing hormone agonist on glucose disposal and insulin secretion.American journal of physiology. Endocrinology and metabolism · 2008Trial
- Acute modulation of adipose tissue lipolysis by intravenous estrogens.Obesity (Silver Spring, Md.) · 2006 · on this mapTrial
- A Critical Assessment of Fasting to Promote Metabolic Health and Longevity.Endocrine reviews · 2025Review
- The Impact of Estrogen Deficiency on Liver Metabolism: Implications for Hormone Replacement Therapy.Endocrine reviews · 2025Review
- Peak Week Carbohydrate Manipulation Practices in Physique Athletes: A Narrative Review.Sports medicine - open · 2024Review
- Body composition and cardiometabolic health across the menopause transition.Obesity (Silver Spring, Md.) · 2022Review
- Review
- In utero low-protein-diet-programmed type 2 diabetes in adult offspring is mediated by sex hormones in rats†.Biology of reproduction · 2020Article
- Estrogen-related mechanisms in sex differences of hypertension and target organ damage.Biology of sex differences · 2020Review
- Sex Hormone-Dependent Physiology and Diseases of Liver.International journal of environmental research and public health · 2020Review
- The Impact of Skeletal Muscle ERα on Mitochondrial Function and Metabolic Health.Endocrinology · 2020Review
- Glucose Management and the Sex Difference in Excess Cardiovascular Disease Risk in Long-Duration Type 1 Diabetes.Current diabetes reports · 2019Review
- Acute estradiol treatment reduces skeletal muscle protein breakdown markers in early- but not late-postmenopausal women.Steroids · 2019Article
- Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats.Frontiers in endocrinology · 2019Article
- Sex-specific effects of maternal and postweaning high-fat diet on skeletal muscle mitochondrial respiration.Journal of developmental origins of health and disease · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To test the hypothesis that estrogens alter insulin action, we evaluated the effects of intravenous conjugated estrogens (CE) on insulin-stimulated steady-state glucose infusion rate (SSGIR) and suppression of plasma glycerol in postmenopausal women (mean +/- SD; 56 +/- 4 yr; n = 12) not using hormone replacement. SSGIR and glycerol were measured during a two-stage (8 and 40 mU. m-2. min-1) hyperinsulinemic euglycemic clamp on 2 days, with or without a 2.5-mg intravenous CE bolus. Serum estradiol concentrations were increased approximately 200% on the estrogen (EST) compared with the control (CON) days. Serum insulin was reduced (P < 0.01) during stage 2 of the clamp for EST (63.3 +/- 12.8 micro U/ml) vs. CON (78.2 +/- 15.8 micro U/ml). Mean SSGIR and plasma glycerol did not differ between CON and EST days. With adjustment for differences in insulin concentration between conditions, stage 2 glucose disposals were significantly higher (8.63 vs. 7.20 mg. kg-1. min-1) and plasma glycerol concentrations were significantly lower (29.4 vs. 35.0 micro mol/l) for EST vs. CON. Our findings suggest that acute CE administration increases insulin clearance and action in postmenopausal women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.