ArticleThe Journal of experimental medicine2003
Ligand-dependent inhibition of CD1d-restricted NKT cell development in mice transgenic for the activating receptor Ly49D.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The α glycolipid rules the NKT cell TCR.The Journal of experimental medicine · 2025Article
- NKT Cells Contribute to the Control of Microbial Infections.Frontiers in cellular and infection microbiology · 2021Review
- The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells.Frontiers in immunology · 2019Review
- Extrinsic allospecific signals of hematopoietic origin dictate iNKT cell lineage-fate decisions during development.Scientific reports · 2016Article
- Role of Innate T Cells in Anti-Bacterial Immunity.Frontiers in immunology · 2015Review
- Evidence for high bi-allelic expression of activating Ly49 receptors.Nucleic acids research · 2009Article
- MHC class II-expressing thymocytes suppress invariant NKT cell development.Immunology and cell biology · 2009Article
- Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- H2-D(d)-mediated upregulation of interleukin-4 production by natural killer T-cell and dendritic cell interaction.Immunology · 2008Article
- Primary infection of C57BL/6 mice with Plasmodium yoelii induces a heterogeneous response of NKT cells.Infection and immunity · 2007Article
- Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes.The Journal of experimental medicine · 2005Article
- Application of natural killer T-cells to posttransplantation immunotherapy.International journal of hematology · 2005Review
- Role of regulatory invariant CD1d-restricted natural killer T-cells in protection against type 1 diabetes.Immunologic research · 2005Review
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Authors and funding
7 authors.
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Abstract
In addition to their CD1d-restricted T cell receptor (TCR), natural killer T (NKT) cells express various receptors normally associated with NK cells thought to act, in part, as modulators of TCR signaling. Immunoreceptor-tyrosine activation (ITAM) and inhibition (ITIM) motifs associated with NK receptors may augment or attenuate perceived TCR signals respectively, potentially influencing NKT cell development and function. ITIM-containing Ly49 family receptors expressed by NKT cells are proposed to play a role in their development and function. We have produced mice transgenic for the ITAM-associated Ly49D and ITIM-containing Ly49A receptors and their common ligand H2-Dd to determine the importance of these signaling interplays in NKT cell development. Ly49D/H2-Dd transgenic mice had selectively and severely reduced numbers of thymic and peripheral NKT cells, whereas both ligand and Ly49D transgenics had normal numbers of NKT cells. CD1d tetramer staining revealed a blockade of NKT cell development at an early precursor stage. Coexpression of a Ly49A transgene partially rescued NKT cell development in Ly49D/H2-Dd transgenics, presumably due to attenuation of ITAM signaling. Thus, Ly49D-induced ITAM signaling is incompatible with the early development of cells expressing semi-invariant CD1d-restricted TCRs and appropriately harmonized ITIM-ITAM signaling is likely to play an important role in the developmental program of NKT cells.
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