ArticleThe EMBO journal2003
Ribosomal protein S15 represses its own translation via adaptation of an rRNA-like fold within its mRNA.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- Extraribosomal Functions of Bacterial Ribosomal Proteins-An Update, 2023.International journal of molecular sciences · 2024Review
- A riboswitch separated from its ribosome-binding site still regulates translation.Nucleic acids research · 2023Article
- Effect of Dietary Betaine on Muscle Protein Deposition, Nucleic Acid and Amino Acid Contents, and Proteomes of Broilers.Animals : an open access journal from MDPI · 2022Article
- Regulation of Ribosomal Protein Synthesis in Mycobacteria: The Autogenous Control ofInternational journal of molecular sciences · 2021Article
- Rerouting of ribosomal proteins into splicing in plant organelles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The role of RNA structure in translational regulation by L7Ae protein in archaea.RNA (New York, N.Y.) · 2019Article
- Fitness advantages conferred by the L20-interacting RNARNA (New York, N.Y.) · 2018Article
- rRNA Mimicry in RNA Regulation of Gene Expression.Microbiology spectrum · 2018Review
- Recognizing RNA structural motifs in HT-SELEX data for ribosomal protein S15.BMC bioinformatics · 2017Article
- RNA regulators responding to ribosomal protein S15 are frequent in sequence space.Nucleic acids research · 2016Article
- Co-evolution of Bacterial Ribosomal Protein S15 with Diverse mRNA Regulatory Structures.PLoS genetics · 2015Article
- Discovery and validation of novel and distinct RNA regulators for ribosomal protein S15 in diverse bacterial phyla.BMC genomics · 2014Article
- Folding a stable RNA pseudoknot through rearrangement of two hairpin structures.Nucleic acids research · 2014Article
- Bacterial RNA motif in the 5' UTR of rpsF interacts with an S6:S18 complex.RNA (New York, N.Y.) · 2014Article
- S6:S18 ribosomal protein complex interacts with a structural motif present in its own mRNA.RNA (New York, N.Y.) · 2013Article
- RNA structures regulating ribosomal protein biosynthesis in bacilli.RNA biology · 2013Article
- Most RNAs regulating ribosomal protein biosynthesis in Escherichia coli are narrowly distributed to Gammaproteobacteria.Nucleic acids research · 2013Article
- Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP.Nature structural & molecular biology · 2011Article
- Article
- Towards deciphering the principles underlying an mRNA recognition code.Current opinion in structural biology · 2008Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The 16S rRNA-binding ribosomal protein S15 is a key component in the assembly of the small ribosomal subunit in bacteria. We have shown that S15 from the extreme thermophile Thermus thermophilus represses the translation of its own mRNA in vitro, by interacting with the leader segment of its mRNA. The S15 mRNA-binding site was characterized by footprinting experiments, deletion analysis and site-directed mutagenesis. S15 binding triggers a conformational rearrangement of its mRNA into a fold that mimics the conserved three-way junction of the S15 rRNA-binding site. This conformational change masks the ribosome entry site, as demonstrated by direct competition between the ribosomal subunit and S15 for mRNA binding. A comparison of the T.thermophilus and Escherichia coli regulation systems reveals that the two regulatory mRNA targets do not share any similarity and that the mechanisms of translational inhibition are different. Our results highlight an astonishing plasticity of mRNA in its ability to adapt to evolutionary constraints, that contrasts with the extreme conservation of the rRNA-binding site.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.