ArticleThe EMBO journal2003
Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- Evidence for vitellogenin DNA-binding in honey bees.Protein science : a publication of the Protein Society · 2025Article
- Plant-Produced Viral Nanoparticles as a Functionalized Catalytic Support for Metabolic Engineering.Plants (Basel, Switzerland) · 2024Article
- Structural basis of DNA binding by the NAC transcription factor ORE1, a master regulator of plant senescence.Plant communications · 2023Article
- Novel Glial Cells Missing-2 (GCM2) variants in parathyroid disorders.European journal of endocrinology · 2022Article
- Five patients with disorders of calcium metabolism presented with GCM2 gene variants.Scientific reports · 2021Observational
- DNA-protein interaction: identification, prediction and data analysis.Molecular biology reports · 2019Review
- DLX3 interacts with GCM1 and inhibits its transactivation-stimulating activity in a homeodomain-dependent manner in human trophoblast-derived cells.Scientific reports · 2017Article
- Global Expressions Landscape of NAC Transcription Factor Family and Their Responses to Abiotic Stresses in Citrullus lanatus.Scientific reports · 2016Article
- DNA-dependent formation of transcription factor pairs alters their binding specificity.Nature · 2015Article
- Generation of mice encoding a conditional null allele of Gcm2.Transgenic research · 2014Article
- Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- In silico analysis on structure and DNA binding mode of AtNAC1, a NAC transcription factor from Arabidopsis thaliana.Journal of molecular modeling · 2014Article
- Elucidating the evolutionary conserved DNA-binding specificities of WRKY transcription factors by molecular dynamics and in vitro binding assays.Nucleic acids research · 2013Article
- Structure, function and networks of transcription factors involved in abiotic stress responses.International journal of molecular sciences · 2013Article
- Re-visiting protein-centric two-tier classification of existing DNA-protein complexes.BMC bioinformatics · 2012Article
- Identification and characterization of C106R, a novel mutation in the DNA-binding domain of GCMB, in a family with autosomal-dominant hypoparathyroidism.Clinical endocrinology · 2012Article
- Structural basis for sequence-specific DNA recognition by an Arabidopsis WRKY transcription factor.The Journal of biological chemistry · 2012Article
- A novel mutation in the GCM2 gene causing severe congenital isolated hypoparathyroidism.Journal of pediatric endocrinology & metabolism : JPEM · 2012Article
- A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion.Molecular and cellular biology · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glia cell missing (GCM) transcription factors form a small family of transcriptional regulators in metazoans. The prototypical Drosophila GCM protein directs the differentiation of neuron precursor cells into glia cells, whereas mammalian GCM proteins are involved in placenta and parathyroid development. GCM proteins share a highly conserved 150 amino acid residue region responsible for DNA binding, known as the GCM domain. Here we present the crystal structure of the GCM domain from murine GCMa bound to its octameric DNA target site at 2.85 A resolution. The GCM domain exhibits a novel fold consisting of two domains tethered together by one of two structural Zn ions. We observe the novel use of a beta-sheet in DNA recognition, whereby a five- stranded beta-sheet protrudes into the major groove perpendicular to the DNA axis. The structure combined with mutational analysis of the target site and of DNA-contacting residues provides insight into DNA recognition by this new type of Zn-containing DNA-binding domain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.