Trial reportWorld journal of gastroenterology2003
The influence of Enteral Nutrition in postoperative patients with poor liver function.
Trial report in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Efficacy and safety of nutrition therapy for patients undergoing abdominal surgery: a systematic review and network meta-analysis.European journal of clinical nutrition · 2025Pooled it
- ESPEN guideline on clinical nutrition in liver disease.Clinical nutrition (Edinburgh, Scotland) · 2019Guideline
- What is the evidence for the use of parenteral nutrition (PN) in critically ill surgical patients: a systematic review and meta-analysis.Techniques in coloproctology · 2018Pooled it
- Nutrition support in hospitalised adults at nutritional risk.The Cochrane database of systematic reviews · 2017Pooled it
- Nutritional support for liver disease.The Cochrane database of systematic reviews · 2012Pooled it
- Nutritional support treatment for severe chronic hepatitis and posthepatitic cirrhosis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2006Trial
- Article
- EASL Clinical Practice Guidelines on nutrition in chronic liver disease.Journal of hepatology · 2019Review
- Characteristics of pulmonary infection after mitral valve repair in patients with metabolic syndrome and its relationship with blood pressure, blood glucose and blood lipid.Experimental and therapeutic medicine · 2018Article
- Early enteral nutrition and total parenteral nutrition on the nutritional status and blood glucose in patients with gastric cancer complicated with diabetes mellitus after radical gastrectomy.Experimental and therapeutic medicine · 2018Article
- Liver - guardian, modifier and target of sepsis.Nature reviews. Gastroenterology & hepatology · 2017Review
- Sarcopenia from mechanism to diagnosis and treatment in liver disease.Journal of hepatology · 2016Review
- Early enteral and parenteral nutritional support after hepatectomy in patients with hepatic carcinoma: a systematic review and meta-analysis.OncoTargets and therapy · 2015Article
- [Diagnosis of and therapy for hepatocellular carcinoma].Zeitschrift fur Gastroenterologie · 2013Article
- Clinical review: The liver in sepsis.Critical care (London, England) · 2012Review
- Postoperative management after hepatic resection.Journal of gastrointestinal oncology · 2012Article
- Parenteral nutrition in liver resection.Journal of nutrition and metabolism · 2012Article
- Polymicrobial interactions: impact on pathogenesis and human disease.Clinical microbiology reviews · 2012Review
- Nutritional aspects in patient undergoing liver resection.Updates in surgery · 2011Review
- The benefit of the supplementation of perioperative branched-chain amino acids in patients with surgical management for hepatocellular carcinoma: a preliminary study.Digestive diseases and sciences · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the safety, rationality and the practicality of enteral nutritional (EN) support in the postoperative patients with damaged liver function and the protective effect of EN on the gut barrier.
methods135 patients with liver function of Child B or C grade were randomly allocated to enteral nutrition group (EN, 65 cases), total parenteral nutrition group (TPN, 40 cases) and control group (CON, 30 cases). Nutritional parameters, hepatic and kidney function indexes were measured at the day before operation, 5th and 10th day after the operation respectively. Comparison was made to evaluate the efficacy of different nutritional support. Urinary concentrations of lactulose(L) and mannitol(M) were measured by pulsed electrochemical detection(HPLC-PED) and the L/M ratio calculated to evaluate their effectiveness on protection of gut barrier.
resultsNo significant damages in hepatic and kidney function were observed in both EN and TPN groups between pre- and postoperatively. EN group was the earliest one reaching the positive nitrogen balance after operation and with the lowest loss of body weight and there was no change in L/M ratio after the operation (0.026+/-0.004) at the day 1 before operation, 0.030+/-0.004 at the day 5 postoperative and 0.027+/-0.005 at the day 10 postoperative), but the change in TPN group was significant at the day 5 postoperative (0.027+/-0.003 vs 0.038+/-0.009,P<0.01).
conclusionEN is a rational and effective method in patients with hepatic dysfunction after operation and has significant protection effect on the gut barrier.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.