ArticleWorld journal of gastroenterology2003
Association of two polymorphisms of tumor necrosis factor gene with acute biliary pancreatitis.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Association between the Lymphotoxin-BioMed research international · 2020Pooled it
- Decreased levels of regulatory B cells in patients with acute pancreatitis: association with the severity of the disease.Oncotarget · 2018Article
- The effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk.Oncotarget · 2017Article
- Tumor necrosis factor-α -308 G/A polymorphism and risk of sepsis, septic shock, and mortality: an updated meta-analysis.Oncotarget · 2017Article
- Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis.Gastroenterology research and practice · 2017Review
- Genetics of acute and chronic pancreatitis: An update.World journal of gastrointestinal pathophysiology · 2014Review
- TNF gene polymorphisms in cystic fibrosis patients: contribution to the disease progression.Journal of translational medicine · 2013Article
- Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility.Experimental and therapeutic medicine · 2011Article
- TLR and MBL gene polymorphisms in severe acute pancreatitis.Molecular diagnosis & therapy · 2008Article
- Expression of PCNA and CD44mRNA in colorectal cancer with venous invasion and its relationship to liver metastasis.World journal of gastroenterology · 2003Article
- TNF-alpha gene (TNFA) variants increase risk for multi-organ dysfunction syndrome (MODS) in acute pancreatitis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate TNF-alpha-308 and TNFB polymorphisms in acute biliary pancreatitis (ABP) and to related them to the plasma TNF-alpha levels.
methodsGenomic DNA was prepared from peripheral blood leukocytes. Genotypes and allele frequencies were determined in patients (n=127) and healthy controls (n=102) using restriction fragment length polymorphism analysis of polymerase chain reaction (PCR) products. Reading the size of digested bands from polyacrylamide gel demonstrated the two alleles TNF1 and TNF2, or the two alleles TNFB1 and TNFB2.
resultsThe frequencies of TNF2 polymorphism and TNFB2 polymorphism were both similar in patients with mild or severe pancreatitis, so were in pancreatitis patients and in controls. Patients with septic shock showed a significantly higher prevalence of the TNF2 than those without. No significant differences were found in the genotype distribution of TNF-alpha-308 and TNFB among different groups. Plasma TNF-alpha levels did not differ significantly in ASBP patients displaying different alleles of the TNF gene studied.
conclusionResults indicate that TNF gene polymorphisms studied play no part in determination of disease severity or susceptibility to acute biliary pancreatitis; however, TNF2 polymorphism is associated with septic shock from ASBP. Genetic factors are not important in determining plasma TNF-alpha levels in ASBP.
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