ArticleWorld journal of gastroenterology2003
Action of progesterone on contractile activity of isolated gastric strips in rats.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Effect of menstrual cycle and menopause on human gastric electrophysiology.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Meta-analysis of the relation between irritable bowel syndrome and antibodies against endogenous gonadotropin-releasing hormone and its receptor.Proceedings (Baylor University. Medical Center) · 2023Review
- Progesterone inhibitory role on gastrointestinal motility.Physiological research · 2022Review
- Diagnostic and Prognostic Impact of Progesterone Receptor Immunohistochemistry: A Study Evaluating More Than 16,000 Tumors.Analytical cellular pathology (Amsterdam) · 2022Article
- Systemic distribution of progesterone receptor subtypes in human tissues.The Journal of steroid biochemistry and molecular biology · 2020Article
- Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells.Biomedical reports · 2018Article
- Gonadotropin-Releasing Hormone and Its Role in the Enteric Nervous System.Frontiers in endocrinology · 2017Review
- Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats.World journal of gastroenterology · 2016Article
- Autoantibodies and gastrointestinal symptoms in infertile women in relation to in vitro fertilization.BMC pregnancy and childbirth · 2013Article
- Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility.Drug target insights · 2012Article
- Gender bias in gastroparesis: is nitric oxide the answer?Digestive diseases and sciences · 2011Review
- The effects of female sexual steroids on gastric function and barrier resistance of gastrointestinal tract following traumatic brain injury.Journal of pharmacy & bioallied sciencesArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the effect of progesterone on contractile activity of isolated gastric strips in rats.
methodsWistar rats were sacrificed to remove whole stomach. Then, the stomach was opened and the mucosal layer was removed. Parallel to either the circular or the longitudinal fibers, muscle strips were cut from fundus, body, antrum and pylorus. Each muscle strip was suspended in a tissue chamber containing 5 mL Krebs solution. Then the motility of gastric strips in tissue chambers was simultaneously recorded. The preparations were subjected to 1 g load tension and washed with 5 ml Krebs solution every 20 min. After 1 h equilibration, progesterone or antagonists were added in the tissue chamber separately. The antagonists were added 3 min before using progesterone (50 micromol/L(-1)).
resultsProgesterone decreased the resting tension of fundus and body longitudinal muscle (LM) (P<0.05). It inhibited the mean contractile amplitude of body and antrum LM and circular muscle (CM), and the motility index of pyloric CM (P<0.05). The inhibition of progesterone on the mean contractile amplitude could be partially blocked by phentolamine in LM of the stomach body (the mean contractile amplitude of body LM decreased from -7.5+/-5.5 to -5.2+/-4.5 P<0.01), and by phentolamine or indomethacin in CM of body (The inhibition of progesterone on the mean contractile amplitude of body CM decreased from -5.6+/-3.0 to -3.6+/-2.7 by phentolamine and from -5.6+/-3.0 to -3.5+/-2.5 by indomethacin, P<0.01). Hexamethonium, propranolol and L-NNA (inhibitor of NO synthetase) didn't affect the action of progesterone (P>0.05).
conclusionThe study suggested that progesterone can inhibit the contractile activity of isolated gastric strips in rats and the mechanism seems to be a direct one except that the action on gastric body is mediated through prostaglandin and adrenergic alpha receptor partly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.