ArticleWorld journal of gastroenterology2003
Influence of methionine/valine-depleted enteral nutrition on nucleic acid and protein metabolism in tumor-bearing rats.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Review
- Asymptomatic giant gastric carcinosarcoma.BMJ case reports · 2023Article
- Gastric Remnant Carcinosarcoma: Case Report and Review of the Literature.Journal of gastrointestinal cancer · 2021Review
- L-methionase: a therapeutic enzyme to treat malignancies.BioMed research international · 2014Review
- Carcinosarcoma of the stomach: a case report.Journal of gastric cancer · 2013Article
- Gastric carcinoma with osteoblastic differentiation.International journal of surgery case reports · 2012Article
- The Janeway gastrostomy tube for recurrent gastric intubations: a novel and simple animal model.Digestive diseases and sciences · 2008Article
- Carcinosarcoma of the stomach: a case report and review of the literature.World journal of gastroenterology · 2007Review
- Amino acid uptake in arterio-venous serum of normal and cancerous colon tissues.World journal of gastroenterology · 2004Article
- Effect of complex amino acid imbalance on growth of tumor in tumor-bearing rats.World journal of gastroenterology · 2003Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of methionine/valine-depleted enteral nutrition (EN) on RNA, DNA and protein metabolism in tumor-bearing (TB) rats.
methodsSprague-Dawlley (SD) rats underwent jejunostomy for nutritional support. A suspension of Walker-256 carcinosarcoma cells was subcutaneously inoculated. 48 TB rats were randomly divided in 4 groups: A, B, C and D. The TB rats had respectively received jejunal feedings supplemented with balanced amino acids, methionine-depleted, balanced amino acids and valine-depleted for 6 days before injection of 740 KBq (3)H- methionine/valine via jejunum. The (3)H incorporation rate of the radioactivity into RNA, DNA and proteins in tumor tissues at 0.5, 1, 2, 4 h postinjection of tracers was assessed with liquid scintillation counter.
resultsIncorporation of (3)H into proteins in groups B and D was (0.500+/-0.020) % to (3.670+/-0.110) % and (0.708+/-0.019) % to (3.813+/-0.076) % respectively, lower than in groups A ((0.659+/-0.055) % to (4.492+/-0.108) %) and C ((0.805+/-0.098) % to (4.180+/-0.018) %). Incorporation of (3)H into RNA, DNA in group B was (0.237+/-0.075) % and (0.231+/-0.052) % respectively, lower than in group A (P<0.01). There was no significant difference in uptake of (3)H by RNA and DNA between group C and D (P>0.05).
conclusionProtein synthesis was inhibited by methionine/valine starvation in TB rats and nucleic acid synthesis was reduced after methionine depletion, thus resulting in suppression of tumor growth.
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