ArticleWorld journal of gastroenterology2003
Expression of estrogen receptor and estrogen receptor messenger RNA in gastric carcinoma tissues.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Development and validation of nomograms for predicting overall survival and cancer-specific survival in female gastric signet-ring cell carcinoma: a SEER database analysis.Translational cancer research · 2026Article
- Supportive care of female hormones in brain health: what and how?Frontiers in pharmacology · 2024Review
- Long noncoding RNA (lncRNA) HOTAIR: Pathogenic roles and therapeutic opportunities in gastric cancer.Genes & diseases · 2022Review
- Protective effects of female reproductive factors on gastric signet-ring cell carcinoma.World journal of clinical cases · 2022Article
- Nationwide cohort study: cholesterol level is inversely related with the risk of gastric cancer among postmenopausal women.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022Article
- Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.Pathology oncology research : POR · 2020Review
- Prognostic impact of FOXF1 polymorphisms in gastric cancer patients.The pharmacogenomics journal · 2018Article
- Sex differences and effects of oestrogen in rat gastric mucosal defence.World journal of gastroenterology · 2017Article
- Estrogen receptors in gastric cancer: Advances and perspectives.World journal of gastroenterology · 2016Review
- Evaluation of estrogen receptor expression and its relationship with clinicopathologic findings in gastric cancer.Advanced biomedical research · 2015Article
- Clinicopathological features and trend changes of gastric carcinoma in Southern China.World journal of gastroenterology · 2014Article
- Article
- Expression of ERα36 in gastric cancer samples and their matched normal tissues.Oncology letters · 2012Article
- Sex-associated difference in estrogen receptor β expression in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric cancers in rats.Comparative medicine · 2011Article
- Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity.Journal of gastrointestinal oncology · 2011Article
- A variant of estrogen receptor-alpha, ER-alpha36 is expressed in human gastric cancer and is highly correlated with lymph node metastasis.Oncology reports · 2010Article
- Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer.British journal of cancer · 2010Article
- Cytochrome P450 aromatase gene (CYP19) expression in gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2008Article
- Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer.World journal of gastroenterology · 2006Article
- Elevated level of spindle checkprotein MAD2 correlates with cellular mitotic arrest, but not with aneuploidy and clinicopathological characteristics in gastric cancer.World journal of gastroenterology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study estrogen receptor (ER) and estrogen receptor messenger RNA (ERmRNA) expression in gastric carcinoma tissues and to investigate their association with the pathologic types of gastric carcinoma.
methodsThe expression of ER and ERmRNA in gastric carcinoma tissues (15 males and 15 females, 42-70 years old) was detected by immunohistochemistry and in situ hybridization, respectively.
resultsThe positive rate of ER (immunohistochemistry) was 33.3 % in males and 46.7 % in females. In Borrmann IV gastric carcinoma ER positive rate was greater than that in other pathologic types, and in poorly differentiated adenocarcinoma and signet ring cell carcinoma the positive rates were greater than those in other histological types of both males and females (P<0.05). The ER was more highly expressed in diffused gastric carcinoma than in non-diffused gastric carcinoma (P<0.05). The ER positive rate was also related to regional lymph nodes metastases (P<0.05), and was significantly higher in females above 55 years old, and higher in males under 55 years old (P<0.05). The ERmRNA (in situ hybridization) positive rate was 73.3 % in males and 86.7 % in females. The ERmRNA positive rates were almost the same in Borrmann I, II, III and IV gastric carcinoma (P>0.05). ERmRNA was expressed in all tubular adenocarcinoma, poorly differentiated adenocarcinoma and signet ring cell carcinoma (P<0.05). The ERmRNA positive rate was related to both regional lymph nodes metastases and gastric carcinoma growth patterns, and was higher in both sexes above 55 years old but without statistical significance (P>0.05). The positive rate of ERmRNA expression by in situ hybridization was higher than that of ER expression by immunohistochemistry (P<0.05).
conclusionERmRNA expression is related to the pathological behaviors of gastric carcinoma, which might help to predict the prognosis and predict the effectiveness of endocrine therapy for gastric carcinoma.
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