ArticleWorld journal of gastroenterology2003
Mutation and methylation of hMLH1 in gastric carcinomas with microsatellite instability.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer.Journal of Cancer · 2021Article
- Essential updates 2017/2018: Recent topics in the treatment and research of gastric cancer in Japan.Annals of gastroenterological surgery · 2019Review
- Microsatellite Instability and Altered Expressions of MLH1 and MSH2 in Gastric CancerAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma.American journal of cancer research · 2018Article
- Association Between hMLH1 Promoter Methylation and Risk of Gastric Cancer: A Meta-Analysis.Frontiers in physiology · 2018Article
- Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma.British journal of cancer · 2017Article
- GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer.BMC cancer · 2016Article
- H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis.Infectious agents and cancer · 2016Article
- Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma.Oncotarget · 2015Article
- Overexpression of SMYD2 contributes to malignant outcome in gastric cancer.British journal of cancer · 2015Article
- Overexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma.British journal of cancer · 2013Article
- Overexpression of TRIM44 contributes to malignant outcome in gastric carcinoma.Cancer science · 2012Article
- RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells.Oncogene · 2012Article
- Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients.Journal of Zhejiang University. Science. B · 2010Article
- Epigenetic DNA hypermethylation in cholangiocarcinoma: potential roles in pathogenesis, diagnosis and identification of treatment targets.Liver international : official journal of the International Association for the Study of the Liver · 2008Review
- Stage IV early gastric cancer: two cases with microsatellite instability.Langenbeck's archives of surgery · 2008Article
- Tumor microsatellite instability in early onset gastric cancer.The Journal of molecular diagnostics : JMD · 2005Article
- Microsatellite instability and gastric non-invasive neoplasia in a high risk population in Cesena, Italy.Journal of clinical pathology · 2005Review
- Mitochondrial microsatellite instability in gastric cancer and its precancerous lesions.World journal of gastroenterology · 2004Article
- Nuclear and mitochondrial DNA microsatellite instability in hepatocellular carcinoma in Chinese.World journal of gastroenterology · 2004Article
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Authors and funding
8 authors.
Funding
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Abstract
aimTo appraise the correlation of mutation and methylation of hMSH1 with microsatellite instability (MSI) in gastric cancers.
methodsMutation of hMLH1 was detected by Two-dimensional electrophoresis (Two-D) and DNA sequencing; Methylation of hMLH1 promoter was measured with methylation-specific PCR; MSI was analyzed by PCR-based methods.
resultsSixty-eight cases of sporadic gastric carcinoma were studied for mutation and methylation of hMLH1 promoter and MSI. Three mutations were found, two of them were caused by a single bp substitution and one was caused by a 2 bp substitution, which displayed similar Two-D band pattern. Methylation of hMLH1 promoter was detected in 11(16.2 %) gastric cancer. By using five MSI markers, MSI in at least one locus was detected in 17/68(25 %) of the tumors analyzed. Three hMLH1 mutations were all detected in MSI-H (>=2 loci, n=8), but no mutation was found in MSI-L (only one locus, n=9) or MSS (tumor lacking MSI or stable, n=51). Methylation frequency of hMLH1 in MSI-H (87.5 %, 7/8) was significantly higher than that in MSI-L (11.1 %, 1/9) or MSS (5.9 %, 3/51) (P<0.01-0.001), but no difference was found between MSI-L and MSS (P>0.05).
conclusionBoth mutation and methylation of hMLH1 are involved in the MSI pathway but not related to the LOH pathway in gastric carcinogenesis.
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