ArticleWorld journal of gastroenterology2003
Translocation of annexin I from cellular membrane to the nuclear membrane in human esophageal squamous cell carcinoma.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Annexin A1: Uncovering the Many Talents of an Old Protein.International journal of molecular sciences · 2018Review
- Expression of annexin-A1 and galectin-1 anti-inflammatory proteins and mRNA in chronic gastritis and gastric cancer.Mediators of inflammation · 2013Article
- None-endoscopic Screening for Esophageal Squamous Cell Carcinoma- A Review.Middle East journal of digestive diseases · 2012Review
- Quantitative tissue proteomics of esophageal squamous cell carcinoma for novel biomarker discovery.Cancer biology & therapy · 2011Article
- Implications of tyrosine phosphoproteomics in cervical carcinogenesis.Journal of carcinogenesis · 2008Article
- Overexpression of annexin 1 in pancreatic cancer and its clinical significance.World journal of gastroenterology · 2004Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the alteration of the annexin I subcellular localization in esophageal squamous cell carcinoma (ESCC) and the correlation between the translocation and the tumorigenesis of ESCC.
methodsThe protein localization of annexin I was detected in both human ESCC tissues and cell line via the indirect immunofluorescence strategy.
resultsIn the normal esophageal epithelia the annexin I was mainly located on the plasma membrane and formed a consecutive typical trammels net. Annexin I protein also expressed dispersively in cytoplasm and the nuclei without specific localization on the nuclear membrane. In esophageal cancer annexin I decreased very sharply with scattered disappearance on the cellular membrane, however it translocated and highly expressed on the nuclear membrane, which was never found in normal esophageal epithelia. In cultured esophageal cancer cell line annexin I protein was also focused on the nuclear membrane, which was consistent with the result from esophageal cancer tissues.
conclusionThis observation suggests that the translocation of annexin I protein in ESCC may correlate with the tumorigenesis of the esophageal cancer.
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