ArticleAmerican journal of human genetics2003
Anxiety with panic disorder linked to chromosome 9q in Iceland.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.European journal of human genetics : EJHG · 2012Pooled it
- Panic disorders: The role of genetics and epigenetics.AIMS genetics · 2018Review
- Commonalities in Development of Pure Breeds and Population Isolates Revealed in the Genome of the Sardinian Fonni's Dog.Genetics · 2016Article
- 'Big data' in mental health research: current status and emerging possibilities.Social psychiatry and psychiatric epidemiology · 2016Review
- Small effective population size and genetic homogeneity in the Val Borbera isolate.European journal of human genetics : EJHG · 2013Article
- The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders.Frontiers in pharmacology · 2013Article
- A survey of putative anxiety-associated genes in panic disorder patients with and without bladder symptoms.Psychiatric genetics · 2012Article
- Linkage analysis of alternative anxiety phenotypes in multiply affected panic disorder families.Psychiatric genetics · 2012Article
- Multivariate analysis of anxiety disorders yields further evidence of linkage to chromosomes 4q21 and 7p in panic disorder families.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- The genetic basis of panic disorder.Journal of Korean medical science · 2011Review
- Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms.Translational psychiatry · 2011Article
- Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism.Translational psychiatry · 2011Article
- Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression.Nature genetics · 2011Article
- Advances in molecular genetics of panic disorder.Molecular psychiatry · 2010Review
- Association analysis of Rgs7 variants with panic disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands.Archives of general psychiatry · 2008Article
- A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.Nature · 2008Article
- Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype.Molecular psychiatry · 2008Article
- Genetic and environmental factors in complex neurodevelopmental disorders.Current genomics · 2007Article
- Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus.American journal of human genetics · 2006Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The results of a genomewide scan for genes conferring susceptibility to anxiety disorders in the Icelandic population are described. The aim of the study was to locate genes that predispose to anxiety by utilizing the extensive genealogical records and the relative homogeneity of the Icelandic population. Participants were recruited in two stages: (1) Initial case-identification by a population screening for anxiety disorders, using the Stamm Screening Questionnaire, was followed by aggregation into extended families, with the help of our genealogy database; and (2) those who fulfilled the diagnostic and family aggregation criteria underwent a more detailed diagnostic workup based on the Composite International Diagnostic Interview. Screening for anxiety in close relatives also identified additional affected members within the families. After genotyping was performed with 976 microsatellite markers, affected-only linkage analysis was done, and allele-sharing LOD scores were calculated using the program Allegro. Linkage analysis of 25 extended families, in each of which at least one affected individual had panic disorder (PD), resulted in a LOD score of 4.18 at D9S271, on chromosome 9q31. The intermarker distance was 4.4 cM on average, whereas it was 1.5 cM in the linked region as additional markers were added to increase the information content. The linkage results may be relevant not only to PD but also to anxiety in general, since our linkage study included patients with other forms of anxiety.
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Registered trials
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