ArticleAmerican heart journal2003
Importance of time-to-reperfusion in patients with acute myocardial infarction with and without cardiogenic shock treated with primary percutaneous coronary intervention.
Article in American heart journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Time-to-reperfusion in patients with acute myocardial infarction and mortality in prehospital emergency care: meta-analysis.BMC emergency medicine · 2020Pooled it
- Trial
- Sex Differences in Management, Time to Intervention, and In-Hospital Mortality of Acute Myocardial Infarction and Non-Myocardial Infarction Related Cardiogenic Shock.medRxiv : the preprint server for health sciences · 2024Article
- Impact of emergency medical service delays on time to reperfusion and mortality in STEMI.Open heart · 2021Observational
- [Cardiogenic shock].Wiener klinische Wochenschrift · 2020Article
- Evolving strategies in the treatment of acute myocardial infarction-induced cardiogenic shock.Annals of cardiothoracic surgery · 2014Article
- Timely reperfusion for ST-segment elevation myocardial infarction: Effect of direct transfer to primary angioplasty on time delays and clinical outcomes.World journal of cardiology · 2014Review
- Have we given up on intra-aortic balloon counterpulsation in post-myocardial infarction cardiogenic shock?Clinical cardiology · 2013Article
- Door-to-balloon time in primary percutaneous coronary intervention predicts degree of myocardial necrosis as measured using cardiac biomarkers.Texas Heart Institute journal · 2010Article
- Association of door-to-balloon time and mortality in patients > or =65 years with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.The American journal of cardiology · 2009Article
- Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study.BMJ (Clinical research ed.) · 2009Article
- Outcomes of contemporary interventional therapy of ST elevation infarction in patients older than 75 years.Clinical cardiology · 2009Article
- Quality of care of patients with acute myocardial infarction in Bulgaria: a cross-sectional study.BMC health services research · 2009Article
- Putting the benefits of percutaneous coronary revascularization into perspective: from trials to guidelines.Current cardiology reports · 2008Review
- Time delay in primary angioplasty: how relevant is it?Heart (British Cardiac Society) · 2007Article
- Delays to reperfusion therapy in acute ST-segment elevation myocardial infarction: results from the AMI-QUEBEC Study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2006Article
- Timing, setting and incidence of cardiovascular complications in patients with acute myocardial infarction submitted to primary percutaneous coronary intervention.The Canadian journal of cardiology · 2006Article
- Cardiogenic shock--an inflammatory disease.Wiener klinische Wochenschrift · 2006Article
- Door-to-Balloon Delays with PCI in Acute Myocardial Infarction.Current treatment options in cardiovascular medicine · 2004Article
- Percutaneous coronary intervention in cardiogenic shock complicating acute ST-elevation myocardial infarction-a single centre experience.Indian heart journalArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTime-to-treatment is important for survival in patients with acute myocardial infarction (AMI) treated with fibrinolytic therapy, but the importance of time-to-treatment with primary percutaneous coronary intervention (PCI) is controversial. Previous studies evaluating the importance of time-to-treatment with primary PCI have not analyzed patients with cardiogenic shock separately.
methodsConsecutive patients with AMI (n = 1843) treated with primary PCI were prospectively enrolled in the LeBauer Cardiovascular Research Foundation Registry. Late clinical follow-up was obtained in 98% of patients, at a mean time of 6.1 years.
resultsReperfusion times were longer in women and patients with diabetes mellitus and shorter in patients with prior myocardial infarction. In patients with shock (n = 138), the inhospital mortality rate increased progressively with increasing time-to-reperfusion (<3 hours, 31%; 3-<6 hours, 50%; > or =6 hours, 62%; P =.01), whereas in patients without shock (n = 1705), inhospital and late mortality rates were similar across 3 categories of time to reperfusion (<3 hours, 5.8%; 3-<6 hours, 4.6%; > or =6 hours, 4.8%; P =.46). After adjusting for differences in baseline variables, reperfusion time was a significant independent predictor of inhospital mortality in patients with shock, but not in patients without shock.
conclusionsReperfusion time with primary PCI is important for survival in patients with shock, but appears to be less important in patients without shock. These data emphasize the importance of achieving early reperfusion in patients with shock and have implications on the triage of patients without shock for mechanical reperfusion and the mechanism of benefit of reperfusion therapy with primary PCI.
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