ArticleHuman genetics2003
Randomly distributed crossovers may generate block-like patterns of linkage disequilibrium: an act of genetic drift.
Article in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Genome wide association mapping and candidate gene analysis for pod shatter resistance in Brassica juncea and its progenitor species.Molecular biology reports · 2020Article
- Linkage disequilibrium and haplotype block structure in a composite beef cattle breed.BMC genomics · 2014Article
- BLOCK-BASED BAYESIAN EPISTASIS ASSOCIATION MAPPING WITH APPLICATION TO WTCCC TYPE 1 DIABETES DATA.The annals of applied statistics · 2011Article
- A detailed Hapmap of the Sitosterolemia locus spanning 69 kb; differences between Caucasians and African-Americans.BMC medical genetics · 2006Article
- Article
- Genome amplification of single sperm using multiple displacement amplification.Nucleic acids research · 2005Article
- Human haplotype block sizes are negatively correlated with recombination rates.Genome research · 2004Article
- Recovering frequencies of known haplotype blocks from single-nucleotide polymorphism allele frequencies.Genetics · 2004Article
- Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations.American journal of human genetics · 2004Article
- Will haplotype maps be useful for finding genes?Molecular psychiatry · 2004Review
- Patterns of linkage disequilibrium in the MHC region on human chromosome 6p.Human genetics · 2004Article
- Population-genetic basis of haplotype blocks in the 5q31 region.American journal of human genetics · 2004Article
- On the applicability of a haplotype map to un-assayed populations.Human genetics · 2004Review
- Gametic phase estimation over large genomic regions using an adaptive window approach.Human genomics · 2003Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is considerable interest in identifying and characterizing block-like patterns of linkage disequilibrium (LD; haplotype blocks) in the human genome as these may facilitate the identification of complex disease genes via genome-wide association studies. Although recombination hot-spots have been suggested as the primary mechanism to explain the block-like pattern of LD, other forces, such as genetic drift, may also be important. To this end, we have studied the effect of various recombination models on patterns of LD by using extensive simulations. As expected, haplotype blocks were observed under a model allowing recombination hot-spots. However, we also observed similar block-like patterns in the models where recombination crossovers are randomly and uniformly distributed, and we demonstrate that these blocks are generated by genetic drift. We caution that genetic drift may be an alternative mechanism (in addition to recombination hot-spots) that can lead to block-like patterns of LD. Our findings highlight the necessity of characterizing haplotype blocks in world-wide populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.