ArticleProceedings of the National Academy of Sciences of the United States of America2003
A secreted high-affinity inhibitor of human TNF from Tanapox virus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Uncovering viral protein acquisition events and human-specific folds with pairwise comparisons of predicted protein structures.Molecular biology and evolution · 2026Article
- TNF Decoy Receptors Encoded by Poxviruses.Pathogens (Basel, Switzerland) · 2021Review
- Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor.Journal of clinical medicine · 2019Article
- [Human poxvirus infections].Annales de dermatologie et de venereologie · 2019Review
- Molluscum contagiosum virus MC80 sabotages MHC-I antigen presentation by targeting tapasin for ER-associated degradation.PLoS pathogens · 2019Article
- Tanapoxvirus lacking the 15L gene inhibits melanoma cell growth in vitro by inducing interferon-λ1 release.Virus genes · 2017Article
- Tanapoxvirus lacking a neuregulin-like gene regresses human melanoma tumors in nude mice.Virus genes · 2017Article
- Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures.Nature reviews. Immunology · 2017Review
- Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors.The Journal of biological chemistry · 2015Article
- Oncolytic tanapoxvirus expressing FliC causes regression of human colorectal cancer xenografts in nude mice.Journal of experimental & clinical cancer research : CR · 2015Article
- Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signaling.Journal of virology · 2014Article
- The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling.The Journal of general virology · 2014Article
- The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells.Journal of virology · 2013Article
- Subversion of cytokine networks by virally encoded decoy receptors.Immunological reviews · 2012Review
- How vaccinia virus has evolved to subvert the host immune response.Journal of structural biology · 2011Review
- The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein.Nature structural & molecular biology · 2009Article
- A method for the generation of ectromelia virus (ECTV) recombinants: in vivo analysis of ECTV vCD30 deletion mutants.PloS one · 2009Article
- M135R is a novel cell surface virulence factor of myxoma virus.Journal of virology · 2007Article
- Optimization of codon usage of poxvirus genes allows for improved transient expression in mammalian cells.Virus genes · 2006Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A class of secreted poxvirus tumor necrosis factor (TNF)-binding proteins has been isolated from Tanapox-infected cell supernatants. The inhibitor bound to a TNF-affinity column and was identified as the product of the 2L gene. Sequence analysis of 2L family members from other yatapoxviruses and swinepox virus yielded no sequence homology to any known cellular gene. The expressed Tanapox virus 2L protein bound to human TNF with high affinity (K(d) = 43 pM) and exhibits an unusually slow off-rate. However, 2L is unable to bind to a wide range of human TNF family members. The 2L protein can inhibit human TNF from binding to TNF receptors I and II as well as block TNF-induced cytolysis. Thus, Tanapox virus 2L represents an inhibitor of human TNF and offers a unique strategy with which to modulate TNF activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.