Evidence map›Paper›PMID 12676722›Full record

ArticleApplied and environmental microbiology2003

Heat shock response by the hyperthermophilic archaeon Pyrococcus furiosus.

Keith R Shockley, Donald E Ward, Swapnil R Chhabra, Shannon B Conners, Clemente I Montero, Robert M Kelly

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keith R ShockleyDepartment of Chemical Engineering, North Carolina State University, Raleigh 27695-7905, USA.
Donald E Ward
Swapnil R Chhabra
Shannon B Conners
Clemente I Montero
Robert M Kelly

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collective transcriptional analysis of heat shock response in the hyperthermophilic archaeon Pyrococcus furiosus was examined by using a targeted cDNA microarray in conjunction with Northern analyses. Differential gene expression suggests that P. furiosus relies on a cooperative strategy of rescue (thermosome [Hsp60], small heat shock protein [Hsp20], and two VAT-related chaperones), proteolysis (proteasome), and stabilization (compatible solute formation) to cope with polypeptide processing during thermal stress.

Indexed as

Gene Expression ProfilingHeat-Shock ResponseOligonucleotide Array Sequence AnalysisTranscription, GeneticArchaeal ProteinsBlotting, NorthernGene Expression Regulation, ArchaealProtein FoldingPyrococcus furiosusArchaeal Proteins

Identifiers

PMID12676722
PMCPMC154833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.