ArticleApplied and environmental microbiology2003
Secretory antibodies do not affect the composition of the bacterial microbiota in the terminal ileum of 10-week-old mice.
Article in Applied and environmental microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- When secretion turns into excretion - the different roles of IgA.Frontiers in immunology · 2022Review
- Bacterial Community Characteristics in the Gastrointestinal Tract of Yak (Animals : an open access journal from MDPI · 2021Article
- Increasing oxygen deficiency changes rare and moderately abundant bacterial communities in coastal soft sediments.Scientific reports · 2019Article
- Pathogen Colonization Resistance in the Gut and Its Manipulation for Improved Health.The American journal of pathology · 2019Review
- Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome.Molecular medicine (Cambridge, Mass.) · 2019Article
- Natural Secretory Immunoglobulins Promote Enteric Viral Infections.Journal of virology · 2018Article
- The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity.Viruses · 2018Review
- Spatial and temporal variability of bacterial communities within a combined sewer system.MicrobiologyOpen · 2016Article
- Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor.Frontiers in immunology · 2016Review
- Tools for T-RFLP data analysis using Excel.BMC bioinformatics · 2014Article
- Impact of T-RFLP data analysis choices on assessments of microbial community structure and dynamics.BMC bioinformatics · 2014Article
- Bacterial community dynamics and activity in relation to dissolved organic matter availability during sea-ice formation in a mesocosm experiment.MicrobiologyOpen · 2014Article
- Article
- Molecular methods for pathogen and microbial community detection and characterization: current and potential application in diagnostic microbiology.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012Review
- Urban stormwater runoff drives denitrifying community composition through changes in sediment texture and carbon content.Microbial ecology · 2011Article
- Phosphorus chemistry and bacterial community composition interact in brackish sediments receiving agricultural discharges.PloS one · 2011Article
- Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development.Infection and immunity · 2010Article
- T-REX: software for the processing and analysis of T-RFLP data.BMC bioinformatics · 2009Article
- Cultivation-independent characterization of methylobacterium populations in the plant phyllosphere by automated ribosomal intergenic spacer analysis.Applied and environmental microbiology · 2008Article
- Overview of the gastrointestinal microbiota.Advances in experimental medicine and biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Terminal restriction fragment length polymorphism (T-RFLP) analysis was conducted on the 16S rRNA genes of the bacterial communities colonizing the epithelial surfaces of the terminal ilea of open conventionally housed mice in an institutional small-animal facility. Polymeric-immunoglobulin-receptor-deficient (pIgR(-/-)) mice that were unable to secrete antibodies across mucosal surfaces were cohoused with normal and otherwise genetically identical wild-type (C57BL/6) mice for 4 weeks. If secretory antibodies played a role in modeling the gastrointestinal microbiota, C57BL/6 mice would have had a more distinct and uniform microbiota than their pIgR(-/-) cage mates. The T-RFLP profiles of the bacterial communities were compared by using Sorensen's pairwise similarity coefficient, a newly developed weighted pairwise similarity coefficient, and on the basis of Shannon's and Simpson's diversity indices. No systematic differences were observed between the dominant components of the mucosa-associated bacterial communities of the terminal ileal walls of the two types of mice, indicating that secretory antibodies do not control the composition of this microbiota. Similar analyses of experiments conducted at two different times, between which the bacterial community composition of the mouse colony in the small-animal facility appeared to have changed, showed that differences could have been detected, had they existed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.