ArticleEnvironmental health perspectives2003
Effects of Chinese domestic polychlorinated biphenyls (PCBs) on gonadal differentiation in Xenopus laevis.
Article in Environmental health perspectives, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Endocrine disrupting chemicals: Impact on human health, wildlife and the environment.Science progress · 2019Review
- Effects of perfluorooctanesulfonate and perfluorobutanesulfonate on the growth and sexual development of Xenopus laevis.Ecotoxicology (London, England) · 2013Article
- Protein expression profiling in the African clawed frog Xenopus laevis tadpoles exposed to the polychlorinated biphenyl mixture aroclor 1254.Molecular & cellular proteomics : MCP · 2009Article
- Intersexuality and the cricket frog decline: historic and geographic trends.Environmental health perspectives · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether polychlorinated biphenyls (PCBs) influence gonadal differentiation in Xenopus laevis, tadpoles were exposed to two Chinese domestic PCBs (PCB3 and PCB5 from Nieuwkoop and Faber stage 46/47 to complete metamorphosis. Gonads were characterized using a dissecting microscope. The control X. laevis had normal ovaries or testes in gross morphology, whereas obviously abnormal testes including ovotestes were found in PCB3- and PCB5-exposed groups. Ovotestes were characterized by morphologic ovaries in the cranial and caudal parts and morphologic testes in the middle part. PCBs did not alter the percentage of females but reduced the percentage of males with morphologically normal testes. The histologic structure of gonads was examined by a series of sections. Morphologically normal and abnormal testes from a few frogs exposed to PCBs were interspersed with oocytes in histologic sections. These testes exhibited looser structure with fewer seminiferous tubes, spermatogonia, and spermatozoa than in controls. The findings suggest that PCB3 and PCB5 have significant feminization effects on gonadal differentiation in X. laevis and that this species is sensitive to endocrine disruption and may be used as a good model to study endocrine disruption.
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